Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside

…, S Ziegler, P Kumar, HJ Wester, R Beck… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The study was performed to compare the 18 F-labeled nitroimidazole compound fluoroazomycin
arabinoside ( 18 F-FAZA) with the standard hypoxia tracer fluoromisonidazole ( 18 F-…

CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer

D Saur, B Seidler, G Schneider, H Algül, R Beck… - Gastroenterology, 2005 - Elsevier
Background & Aims: Expression of the Gi-protein-coupled chemokine receptor CXCR4 has
recently been linked to increased proliferation, invasion, and migration of human pancreatic …

Glial activation and glucose metabolism in a transgenic amyloid mouse model: a triple-tracer PET study

…, V Korzhova, NL Albert, R Beck… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Amyloid imaging by small-animal PET in models of Alzheimer disease (AD) offers the possibility
to track amyloidogenesis and brain energy metabolism. Because microglial activation is …

Radiohybrid ligands: a novel tracer concept exemplified by 18F-or 68Ga-labeled rhPSMA inhibitors

A Wurzer, D Di Carlo, A Schmidt, R Beck… - Journal of Nuclear …, 2020 - Soc Nuclear Med
When we critically assess the reason for the current dominance of 68 Ga-labeled peptides
and peptide-like ligands in radiopharmacy and nuclear medicine, we have to conclude that …

Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine

R Beck, B Röper, JM Carlsen… - Journal of Nuclear …, 2007 - Soc Nuclear Med
We evaluated the predictive value of PET using the hypoxia tracer 18 F-fluoroazomycin
arabinoside ( 18 F-FAZA) for success of radiotherapy in combination with tirapazamine, a …

Synthesis and preclinical characterization of the PSMA-targeted hybrid tracer PSMA-I&F for nuclear and fluorescence imaging of prostate cancer

…, A Wurzer, K Wissmiller, R Beck… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The prostate-specific membrane antigen (PSMA)–targeted radiotracers 68 Ga/ 177 Lu-PSMA-I&T
and 99m Tc-PSMA-I&S (for imaging and surgery) are currently successfully used for …

[HTML][HTML] N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus

L Günther, R Beck, G Xiong, H Potschka, K Jahn… - PLoS one, 2015 - journals.plos.org
An acute unilateral vestibular lesion leads to a vestibular tone imbalance with nystagmus,
head roll tilt and postural imbalance. These deficits gradually decrease over days to weeks …

Sequential [18F]FDG µPET whole-brain imaging of central vestibular compensation: a model of deafferentation-induced brain plasticity

A Zwergal, J Schlichtiger, G Xiong, R Beck… - Brain Structure and …, 2016 - Springer
Unilateral inner ear damage is followed by a rapid behavioural recovery due to central
vestibular compensation. In this study, we utilized serial [ 18 F]Fluoro-deoxyglucose ([ 18 F]FDG)-…

[HTML][HTML] Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

A Wurzer, M Parzinger, M Konrad, R Beck, T Günther… - EJNMMI research, 2020 - Springer
Introduction Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted
radiopharmaceuticals, can be labeled either with [ 18 F]fluorine via isotopic …

Selective targeting of integrin αvβ8 by a highly active cyclic peptide

…, UK Marelli, J Notni, A Wurzer, R Beck… - Journal of medicinal …, 2019 - ACS Publications
Integrins play important roles in physiological and pathophysiological processes. Among
the RGD-recognizing integrin subtypes, the αvβ8 receptor is emerging as an attractive target …