Loss of heterozygosity of chromosome 10q has been reported in approximately 40% of
endometrial carcinomas. PTEN, a candidate tumor suppressor gene located at chromosome …

A combined study of zircon U–Pb and Lu–Hf isotopes, mineral O isotopes, whole-rock elements
and Sr–Nd isotopes was carried out for Neoproterozoic volcanics and granites from the …

Recent studies have focused on whether different hepatitis C virus (HCV) genotypes are
associated with different profiles of pathogenicity, infectivity, and response to antiviral therapy. …

A combined study of geochronology and geochemistry was carried out for Neoproterozoic
granodiorites at the southeastern margin of the Yangtze Block in South China. The results …

In the social context of enhancing environmental quality and mitigating climate change, the
improvement of carbon emission efficiency has emerged as a hot topic recently due to its …

The Wnt pathway regulates cell fate, proliferation, and apoptosis, and defects in the pathway
play a key role in many cancers. Although Wnts act to stabilize β-catenin levels in the …

Biologically and clinically meaningful tumor classification schemes have long been sought.
Some malignant epithelial neoplasms, such as those in the thyroid and endometrium, exhibit …

Viroids and most viral satellites have small, noncoding, and highly structured RNA genomes.
How they cause disease symptoms without encoding proteins and why they have …

Background PD-1 inhibitor plus chemotherapy had been shown to be an effective first-line
treatment for patients with metastatic non-small-cell lung cancer (NSCLC). However, there …

Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events
when earlier events are improperly executed. Here we describe evidence for the participation …