The α V β 3 integrin is implicated in human tumor metastasis and in angiogenesis. The design
of low-molecular-mass α V β 3 antagonists by “spatial screening” led to the highly active …

The α v β 3 integrin is an important cell adhesion receptor involved in tumor-induced
angiogenesis and tumor metastasis. Here we describe the 18 F-labeling of the RGD-containing …

The α V β 3 integrin plays an important role in metastasis and tumor-induced angiogenesis.
Targeting with radiolabeled ligands of the α V β 3 integrin may provide information about the …

Background The integrin αvβ3 plays an important role in angiogenesis and tumor cell
metastasis, and is currently being evaluated as a target for new therapeutic approaches. Several …

Cell–cell and cell–matrix interactions play a major role in biology. An important class of surface
receptors are the integrins, which exist in a number of subtypes and are involved in many …

MATERIALS AND METHODS All chemicals were used as supplied without further purification.
Except for N-methylpyrrolidone (NMP), all organic solvents were distilled before use. The 9…

Purpose: The integrin α v β 3 plays a key role in angiogenesis and tumor cell metastasis
and is therefore an important target for new therapeutic and diagnostic strategies. We have …

It has been demonstrated in various murine tumor models that radiolabeled RGD-peptides
can be used for noninvasive determination of αvβ3 integrin expression. Introduction of sugar …

A variety of therapeutic strategies in oncology are focused on the inhibition of tumor-induced
angiogenesis. Thus, there is a keen interest in methods which allow non-invasive …

Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms
leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive …