Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different
patterns of airway remodeling, which all include an increased mass of bronchial smooth …

The chronic inflammatory response within the airways of asthmatics is associated with structural
changes termed airway remodeling. This remodeling process is a key feature of severe …

Airway remodeling with smooth muscle cell (SMC) hyperplasia is a feature of chronic asthma.
We investigated the potential for tryptase, the major secretory product of human mast cells, …

1 This study investigates the role of nitric oxide (NO) and reactive oxygen species (ROS) on
endothelial function of pulmonary arteries in a mice model of hypoxia‐induced pulmonary …

Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the
concentration of which is increased in asthmatic patients. HASMC also induce mast cell …

Asthmatic patients have higher numbers of mast cells in the smooth muscle layer of airways
than normal subjects. Human airway smooth muscle cells (HASMCs) are a source of various …

PURPOSE: To design and validate a dedicated software tool to measure airway dimensions
on thin-section computed tomographic (CT) images and to use the tool to prospectively …

Rationale: Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass,
contributes to bronchial obstruction in asthma. However, its mechanisms are complex and …

Pulmonary artery (PA) hypertension was studied in a chronic hypoxic-pulmonary hypertension
model (7–21 days) in the rat. Increase in PA pressure (measured by catheterism), cardiac …

Purpose To analyze and compare computed tomographic (CT) bronchial measurements in
patients with asthma and healthy subjects and to correlate bronchial morphometric …