User profiles for Rilei Yu
 | Rilei YuVerified email at bioch.ox.ac.uk Cited by 2107 |
[HTML][HTML] Pathophysiology of obesity and its associated diseases
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer, …
studies have indicated that obesity strongly contributes to the development of cancer, …
Progress in developing MNK inhibitors
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
ConoServer ( http://www.conoserver.org ) is a database specializing in the sequences and
structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails …
structures of conopeptides, which are toxins expressed by marine cone snails. Cone snails …
Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor
α-Conotoxins are disulfide-rich and well-structured peptides, most of which can block
nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency. There are …
nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency. There are …
Fructose-1, 6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour …
Tumour cells exhibit greater metabolic plasticity than normal cells and possess selective
advantages for survival and proliferation with unclearly defined mechanisms. Here we …
advantages for survival and proliferation with unclearly defined mechanisms. Here we …
[PDF][PDF] Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …
Determination of the α-conotoxin Vc1. 1 binding site on the α9α10 nicotinic acetylcholine receptor
α-Conotoxin Vc1.1 specifically and potently inhibits the nicotinic acetylcholine receptor subtype
α9α10 (α9α10 nAChR) and is a potential novel treatment for neuropathic pain. Here, we …
α9α10 (α9α10 nAChR) and is a potential novel treatment for neuropathic pain. Here, we …
Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
…, X Wang, Z Lu, D Chong, JY Wang, R Yu, W Yu… - Cell Death & …, 2023 - nature.com
Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine,
with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in …
with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in …
[PDF][PDF] SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
Glutaminase regulates glutaminolysis to promote cancer cell proliferation. However, the
mechanism underlying glutaminase activity regulation is largely unknown. Here, we …
mechanism underlying glutaminase activity regulation is largely unknown. Here, we …
Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth
Impairment of the circadian clock is linked to cancer development. However, whether the
circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we …
circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we …
