[HTML][HTML] COVID-19 in cancer patients: risk, clinical features, and management

C Liu, Y Zhao, D Okwan-Duodu, R Basho… - Cancer biology & …, 2020 - ncbi.nlm.nih.gov
A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has spread across the world, prompting the World Health Organization to declare the …

Targeting the PI3K/AKT/mTOR pathway for the treatment of mesenchymal triple-negative breast cancer: evidence from a phase 1 trial of mTOR inhibition in …

RK Basho, M Gilcrease, RK Murthy, T Helgason… - JAMA …, 2017 - jamanetwork.com
Importance Triple-negative breast cancer (TNBC) classified by transcriptional profiling as
the mesenchymal subtype frequently harbors aberrations in the phosphoinositide 3-kinase (…

[HTML][HTML] Breast cancer liver metastasis: Pathogenesis and clinical implications

C Liu, SC Mohan, J Wei, E Seki, M Liu, R Basho… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the most common malignant disease in female patients worldwide and can
spread to almost every place in the human body, most frequently metastasizing to lymph …

Longitudinal SARS-CoV-2 mRNA vaccine-induced humoral immune responses in patients with cancer

…, R Paquette, AC Mita, R Vescio, I Mehmi, R Basho… - Cancer research, 2021 - AACR
Long-term studies of immunogenicity of SARS-CoV-2 vaccines in patients with cancer are
needed to inform evidence-based guidelines for booster vaccinations and to tailor sequence …

[PDF][PDF] Evaluating the impact of age on immune checkpoint therapy biomarkers

…, M Topper, S Baylin, M Lippman, C Isaacs, R Basho… - Cell reports, 2021 - cell.com
Both tumors and aging alter the immune landscape of tissues. These interactions may play
an important role in tumor progression among elderly patients and may suggest …

Survival Outcomes by TP53 Mutation Status in Metastatic Breast Cancer

…, C Tapia, AK Eterovic, RK Basho… - JCO precision …, 2018 - ascopubs.org
Purpose To determine the significant genomic alterations in patients with metastatic breast
cancer (MBC) and survival outcomes in common genotypes. Patients and Methods High-…

[HTML][HTML] Standardized definitions for efficacy end points in neoadjuvant breast cancer clinical trials: NeoSTEEP

…, L Amiri-Kordestani, RK Basho… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
PURPOSE The Standardized Definitions for Efficacy End Points (STEEP) criteria, established
in 2007 and updated in 2021 (STEEP 2.0), provide standardized definitions of adjuvant …

Abstract PD1-06: Open label phase 1b/2 study of ladiratuzumab vedotin in combination with pembrolizumab for first-line treatment of patients with unresectable locally …

H Han, S Diab, C Alemany, R Basho… - Cancer research, 2020 - AACR
Background Ladiratuzumab vedotin (LV) is an investigational anti-LIV-1 antibody-drug
conjugate with a protease-cleavable linker to monomethyl auristatin E (MMAE). LIV-1 is highly …

Advances in Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer

S Ziyeh, L Wong, RK Basho - Current Oncology Reports, 2023 - Springer
Purpose of Review To provide an overview of the current management of hormone receptor-positive
(HR +) advanced breast cancer as well as highlight ongoing clinical investigation …

Comparative effectiveness of an mTOR‐based systemic therapy regimen in advanced, metaplastic and nonmetaplastic triple‐negative breast cancer

RK Basho, C Yam, M Gilcrease, RK Murthy… - The …, 2018 - academic.oup.com
Background Triple‐negative breast cancer (TNBC) is a heterogeneous disease with
subtypes having different “targetable” molecular aberrations. Metaplastic breast cancers (MpBCs) …