Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

Q Shi, L Qin, W Wei, F Geng, R Fan… - Proceedings of the …, 2012 - National Acad Sciences
We describe a microchip designed to quantify the levels of a dozen cytoplasmic and membrane
proteins from single cells. We use the platform to assess protein–protein interactions …

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

C Ma, R Fan, H Ahmad, Q Shi, B Comin-Anduix… - Nature medicine, 2011 - nature.com
Cellular immunity has an inherent high level of functional heterogeneity. Capturing the full
spectrum of these functions requires analysis of large numbers of effector molecules from …

High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients

…, Y Li, JR Heath, W Wei, S Lu, Q Shi - Proceedings of the …, 2017 - National Acad Sciences
Malignant pleural effusion (MPE), the presence of malignant cells in pleural fluid, is often
the first sign of many cancers and occurs in patients with metastatic malignancies. Accurate …

Single cell proteomics in biomedicine: High‐dimensional data acquisition, visualization, and analysis

Y Su, Q Shi, W Wei - Proteomics, 2017 - Wiley Online Library
New insights on cellular heterogeneity in the last decade provoke the development of a
variety of single cell omics tools at a lightning pace. The resultant high‐dimensional single cell …

[HTML][HTML] An integrated microfluidic chip system for single-cell secretion profiling of rare circulating tumor cells

…, B Yu, DM Czajkowsky, B Liu, Y Li, W Wei, Q Shi - Scientific reports, 2014 - nature.com
Genetic and transcriptional profiling, as well as surface marker identification of single
circulating tumor cells (CTCs) have been demonstrated. However, quantitatively profiling of …

Ordered Mesoporous Metallic MoO2 Materials with Highly Reversible Lithium Storage Capacity

Y Shi, B Guo, SA Corr, Q Shi, YS Hu, KR Heier… - Nano …, 2009 - ACS Publications
Highly ordered mesoporous crystalline MoO 2 materials with bicontinuous Ia3d mesostructure
were synthesized by using phosphomolybdic acid as a precursor and mesoporous silica …

A self-powered, one-step chip for rapid, quantitative and multiplexed detection of proteins from pinpricks of whole blood

J Wang, H Ahmad, C Ma, Q Shi, O Vermesh… - Lab on a Chip, 2010 - pubs.rsc.org
We describe an automated, self-powered chip based on lateral flow immunoassay for rapid,
quantitative, and multiplex protein detection from pinpricks of whole blood. The device …

Facile RAFT precipitation polymerization for the microwave-assisted synthesis of well-defined, double hydrophilic block copolymers and nanostructured hydrogels

Z An, Q Shi, W Tang, CK Tsung… - Journal of the …, 2007 - ACS Publications
Water-soluble macromolecular chain transfer agents (Macro-CTAs) were developed for the
microwave-assisted precipitation polymerization of N-isopropylacrylamide. Two types of …

Selective shortening of single-crystalline gold nanorods by mild oxidation

CK Tsung, X Kou, Q Shi, J Zhang… - Journal of the …, 2006 - ACS Publications
Gold nanorods (NRs) have received much attention due to their size-dependent surface
plasmon-related optical properties. A seed-mediated approach has recently been developed for …

Spherical bioactive glass with enhanced rates of hydroxyapatite deposition and hemostatic activity

TA Ostomel, Q Shi, CK Tsung, H Liang, GD Stucky - Small, 2006 - Wiley Online Library
Bioactive glasses, which can be described by the general chemical formula SiO2ÀCaOÀP2O5ÀMO
(M= Na, Mg, etc.), are used for bone and dental reconstruction because of their …