Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues
P Yao, P Xiao, Z Huang, M Tang, X Tang, G Yang… - Nature Cancer, 2023 - nature.com
Detecting and targeting precancerous cells in noncancerous tissues is a major challenge
for cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-…
for cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-…
MicroRNA-451 negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase–mediated gluconeogenesis
…, M Yang, Y Zhao, X Chen, F Zhang, N Li, P Yao… - Diabetes, 2016 - Am Diabetes Assoc
MicroRNAs (miRNAs) are a new class of regulatory molecules implicated in type 2 diabetes,
which is characterized by insulin resistance and hepatic glucose overproduction. We show …
which is characterized by insulin resistance and hepatic glucose overproduction. We show …
Fpr2 deficiency alleviates diet-induced insulin resistance through reducing body weight gain and inhibiting inflammation mediated by macrophage chemotaxis and M1 …
X Chen, S Zhuo, T Zhu, P Yao, M Yang, H Mei, N Li… - Diabetes, 2019 - Am Diabetes Assoc
Obesity and related inflammation are critical for the pathogenesis of insulin resistance, but
the underlying mechanisms are not fully understood. Formyl peptide receptor 2 (FPR2) plays …
the underlying mechanisms are not fully understood. Formyl peptide receptor 2 (FPR2) plays …
Chronic low-dose cadmium exposure impairs cutaneous wound healing with defective early inflammatory responses after skin injury
H Mei, P Yao, S Wang, N Li, T Zhu, X Chen… - Toxicological …, 2017 - academic.oup.com
Impairment of the immune system is a developing concern in evaluating the toxicity of cadmium
(Cd). In the present study, we investigated if Cd could impair cutaneous wound healing …
(Cd). In the present study, we investigated if Cd could impair cutaneous wound healing …
[HTML][HTML] Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels
…, Z Li, X Ye, B Deng, S Zhuo, P Yao… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs),
is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have …
is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have …
Androgen alleviates neurotoxicity of β‐amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ
PL Yao, S Zhuo, H Mei, XF Chen, N Li… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims Lower androgen level in elderly men is a risk factor of Alzheimer's disease ( AD ). It has
been reported that androgen reduces amyloid peptides (Aβ) production and increases Aβ …
been reported that androgen reduces amyloid peptides (Aβ) production and increases Aβ …
Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway
H Mou, Z Li, P Yao, S Zhuo, W Luan, B Deng… - … International Journal of …, 2013 - Elsevier
FAM3B, also named PANDER, is a cytokine-like protein identified in 2002. Previous studies
showed that FAM3B regulates glucose and lipid metabolism through interaction with liver …
showed that FAM3B regulates glucose and lipid metabolism through interaction with liver …
[HTML][HTML] Nanofiltration for drinking water treatment: a review
In recent decades, nanofiltration (NF) is considered as a promising separation technique to
produce drinking water from different types of water source. In this paper, we …
produce drinking water from different types of water source. In this paper, we …
Dissecting the role of substrate on the morphology and separation properties of thin film composite polyamide membranes: seeing is believing
Recent studies show that the surface morphology of a thin film composite (TFC) polyamide
membrane depends strongly on its porous substrate. Nevertheless, the underlining …
membrane depends strongly on its porous substrate. Nevertheless, the underlining …
Tweak in puzzle: tailoring membrane chemistry and structure toward targeted removal of organic micropollutants for water reuse
Membrane-based water reuse through reverse osmosis (RO) and nanofiltration (NF) faces a
critical challenge from organic micropollutants (OMPs). Conventional polyamide RO and NF …
critical challenge from organic micropollutants (OMPs). Conventional polyamide RO and NF …