[HTML][HTML] Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
H Shi, P Chai, R Jia, X Fan - Molecular cancer, 2020 - Springer
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms. The …
necessary reactions, and these modifications play roles in essential molecular mechanisms. The …
[HTML][HTML] Effects of cancer on patients with COVID-19: a systematic review and meta-analysis of 63,019 participants
L Yang, P Chai, J Yu, X Fan - Cancer Biology & Medicine, 2021 - ncbi.nlm.nih.gov
Objective: Patients with underlying diseases are more vulnerable to coronavirus disease
2019 (COVID-19). The purpose of this study was to investigate cancer incidence in patients …
2019 (COVID-19). The purpose of this study was to investigate cancer incidence in patients …
[HTML][HTML] Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
S Wang, P Chai, R Jia, R Jia - Molecular cancer, 2018 - Springer
N6-methyladenosine (m 6 A), the most prevalent modification of mammalian RNA, has
received increasing attention. Although m 6 A has been shown to be associated with biological …
received increasing attention. Although m 6 A has been shown to be associated with biological …
[HTML][HTML] Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
Background Histone lactylation, a metabolic stress-related histone modification, plays an
important role in the regulation of gene expression during M1 macrophage polarization. …
important role in the regulation of gene expression during M1 macrophage polarization. …
[HTML][HTML] Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer …
The novel coronavirus (2019-nCoV) is an emerging causative agent that was first described
in late December 2019 and causes a severe respiratory infection in humans. Notably, many …
in late December 2019 and causes a severe respiratory infection in humans. Notably, many …
Emancipating target‐functionalized carbon dots from autophagy vesicles for a novel visualized tumor therapy
Killing the tumor cells by a visualized targeting system is a promising strategy with which to
achieve high efficiency, low side effects, and a high survival rate for tumor therapy. Here, an …
achieve high efficiency, low side effects, and a high survival rate for tumor therapy. Here, an …
[HTML][HTML] Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis
…, A Zhuang, X Gu, Y Hua, L Yang, S Ge, J Ruan, P Chai… - Cell Discovery, 2023 - nature.com
Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential
immunotherapies in cancer 1 , 2 . PD-L1 has been detected in the nucleus in multiple …
immunotherapies in cancer 1 , 2 . PD-L1 has been detected in the nucleus in multiple …
[HTML][HTML] m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation
R Jia, P Chai, S Wang, B Sun, Y Xu, Y Yang, S Ge… - Molecular cancer, 2019 - Springer
Background Dynamic N 6 -methyladenosine (m 6 A) RNA modification generated and
erased by N 6 -methyltransferases and demethylases regulates gene expression, alternative …
erased by N 6 -methyltransferases and demethylases regulates gene expression, alternative …
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
T Ge, X Gu, R Jia, S Ge, P Chai… - Cancer …, 2022 - Wiley Online Library
Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …
The m6A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation
Y Xu, X He, S Wang, B Sun, R Jia, P Chai, F Li, Y Yang… - Oncogene, 2022 - nature.com
N 6 -methyladenosine (m 6 A) is the most universal internal RNA modification on messenger
RNAs and regulates the fate and functions of m 6 A-modified transcripts through m 6 A-…
RNAs and regulates the fate and functions of m 6 A-modified transcripts through m 6 A-…