Functional imaging of human epidermal growth factor receptor 2–positive metastatic breast cancer using 64Cu-DOTA-trastuzumab PET
…, DM Colcher, PS Conti, PH Frankel… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Women with human epidermal growth factor receptor 2 (HER2)–positive breast cancer are
candidates for treatment with the anti-HER2 antibody trastuzumab. Assessment of HER2 …
candidates for treatment with the anti-HER2 antibody trastuzumab. Assessment of HER2 …
[HTML][HTML] Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
RS Esworthy, L Yang, PH Frankel, FF Chu - The Journal of nutrition, 2005 - Elsevier
Mice deficient in 2 intracellular selenium (Se)-dependent glutathione peroxidases (Gpx1 and
Gpx2), by genetically disrupting both alleles of the Gpx1 and Gpx2 genes (Gpx1 −/− Gpx2 −/…
Gpx2), by genetically disrupting both alleles of the Gpx1 and Gpx2 genes (Gpx1 −/− Gpx2 −/…
[HTML][HTML] Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients
…, J Mortimer, S Yost, W Guo, C Ruel, PH Frankel… - JCI insight, 2019 - ncbi.nlm.nih.gov
CD8+ tumor-infiltrating lymphocytes (TILs) correlate with relapse-free survival (RFS) in most
cancer types, including breast cancer. However, subset composition, functional status, and …
cancer types, including breast cancer. However, subset composition, functional status, and …
Efficacy of the PARP Inhibitor Veliparib with Carboplatin or as a Single Agent in Patients with Germline BRCA1- or BRCA2-Associated Metastatic Breast Cancer …
G Somlo, PH Frankel, BK Arun, CX Ma, AA Garcia… - Clinical Cancer …, 2017 - AACR
Purpose: We aimed to establish the MTD of the poly (ADP-ribose) (PAR) polymerase
inhibitor, veliparib, in combination with carboplatin in germline BRCA1- and BRCA2- (BRCA)-…
inhibitor, veliparib, in combination with carboplatin in germline BRCA1- and BRCA2- (BRCA)-…
[HTML][HTML] Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised …
F Chiuppesi, JA Zaia, PH Frankel, R Stan… - The Lancet …, 2022 - thelancet.com
Background COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing
SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and …
SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and …
A phase II clinical trial of pembrolizumab and enobosarm in patients with androgen receptor‐positive metastatic triple‐negative breast cancer
Y Yuan, JS Lee, SE Yost, PH Frankel, C Ruel… - The …, 2021 - academic.oup.com
Lessons Learned The combination of enobosarm and pembrolizumab was well tolerated
and showed a modest clinical benefit rate of 25% at 16 weeks. Future trials investigating …
and showed a modest clinical benefit rate of 25% at 16 weeks. Future trials investigating …
[HTML][HTML] Phase I/II trial of palbociclib, pembrolizumab and letrozole in patients with hormone receptor-positive metastatic breast cancer
Y Yuan, JS Lee, SE Yost, PH Frankel, C Ruel… - European Journal of …, 2021 - Elsevier
Background CDK4/6 inhibitors modulate immune response in breast cancer. This phase I/II
trial was designed to test the safety and efficacy of palbociclib, pembrolizumab and letrozole …
trial was designed to test the safety and efficacy of palbociclib, pembrolizumab and letrozole …
[BOOK][B] Essentials of petroleum
PH Frankel - 2012 - api.taylorfrancis.com
… Frankel's native tongue. Equally obvious is his firsthand experience. He might have
written a once interesting now forgotten commentary. … PH Frankel … This kind of thought …
written a once interesting now forgotten commentary. … PH Frankel … This kind of thought …
Tumor uptake of 64Cu-DOTA-trastuzumab in patients with metastatic breast cancer
…, JR Bading, JM Park, PH Frankel… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The goal of this study was to characterize the relationship between tumor uptake of 64 Cu-DOTA-trastuzumab
as measured by PET/CT and standard, immunohistochemistry (IHC)-based…
as measured by PET/CT and standard, immunohistochemistry (IHC)-based…
Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells
…, C Wang, D Tully, CM Kowolik, DM Lu, PH Frankel… - Cancer letters, 2015 - Elsevier
Baicalein is a natural flavone that exhibits anticancer properties. Using microarrays we found
that DDIT4 was the highest transcript induced by baicalein in cancer cells. We confirmed in …
that DDIT4 was the highest transcript induced by baicalein in cancer cells. We confirmed in …