Exosomes are discrete populations of small (40-200 nm in diameter) membranous vesicles
that are released into the extracellular space by most cell types, eventually accumulating in …

Exosomes carry and transmit signaling molecules used for intercellular communication. The
generation and secretion of exosomes is a multistep interlocking process that allows …

The tumor microenvironment (TME) is a complex multicellular functional compartment that
includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (…

Objectives: To investigate the expression of Igγ-1 chain C region (IGHG1) in human
pancreatic carcinomas and determine the biological function of IGHG1 expression in immune …

Background Recently, Accumulating evidence indicates that long noncoding RNAs (lncRNAs)
have been shown to have critical regulatory roles in human tumor biology and …

Mosquito‐borne flaviviruses including Zika virus (ZIKV) represent a public health problem in
some parts of the world. Although ZIKV infection is predominantly asymptomatic or …

Background DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in
several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. …

PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor
cells achieve their expression remains to be addressed. Here, we find that PD-L1 and PD-L2 …

Overexpression of Flap endonuclease 1 (FEN1) has been previously implicated in hepatocellular
carcinoma (HCC), while its expression features and mechanisms remain unclear. In …

Background and aim Nucleolar and spindle-associated protein 1 (NUSAP1) is an indispensable
mitotic regulator. Aberrant NUSAP1 expression is associated with perturbed mitosis and …