Understanding tumor metabolism is important for the development of anticancer therapies.
Immunohistochemical evaluation of colorectal adenocarcinomas showed that cancer cells …

OBJECTIVES: We investigated whether the mean platelet volume would be a useful marker
in the evaluation of inflammatory bowel disease activity. METHODS: Complete blood count, …

Purpose : Hypoxia-inducible factors HIF1α and HIF2α (HIFαs) regulate the expression of a
variety of genes encoding proteins related to angiogenesis and to anaerobic metabolism of …

Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to
lactate, having a principal position in the anaerobic cellular metabolism. Induction of LDH-5 …

Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is
involved in the reversible metabolism of the carbon dioxide to carbonic acid. Up-regulation of …

Radiation pneumonitis and subsequent radiation pulmonary fibrosis are the two main dose-limiting
factors when irradiating the thorax that can have severe implications for patients’ …

Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular
response to hypoxia. Because the efficacy of photodynamic therapy (PDT) is dependent on …

Purpose Randomized controlled trials have generally shown a benefit from accelerated
radiotherapy in head and neck squamous cell carcinoma (HNSCC). However, the large …

Different vascular endothelial growth factor (VEGF) gene polymorphisms have been shown
to result in different VEGF gene responsiveness to various stimuli and different capacity for …

Lactate dehydrogenase 5 (LDH5) is one of the five LDH isoenzymes and, apparently, the
most important for promoting anaerobic glycolysis. LDH5 is transcriptionally regulated by the …