User profiles for Michael G. Tomlinson
 | Michael G TomlinsonAssociate Professor/Reader, School of Biosciences, University of Birmingham Verified email at bham.ac.uk Cited by 5431 |
[BOOK][B] The leucocyte antigen factsbook
…, MH Brown, SKAKA Law, AJ McKnight, MG Tomlinson… - 1997 - books.google.com
A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook
was hugely successful. The new Second Edition has been completely revised, updated, …
was hugely successful. The new Second Edition has been completely revised, updated, …
The ins and outs of the transmembrane 4 superfamily
MD Wright, MG Tomlinson - Immunology today, 1994 - cell.com
… 46), although G-protein inhibitors have no effect on CD53-mediated mobilization of
intraceUular calcium stores 42. Conversely, inhibitors of tyrosine kinases can abolish signal …
intraceUular calcium stores 42. Conversely, inhibitors of tyrosine kinases can abolish signal …
[HTML][HTML] The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade
GLJ Fuller, JAE Williams, MG Tomlinson… - Journal of Biological …, 2007 - ASBMB
The two lectin receptors, CLEC-2 and Dectin-1, have been shown to signal through a Syk-dependent
pathway, despite the presence of only a single YXXL in their cytosolic tails. In this …
pathway, despite the presence of only a single YXXL in their cytosolic tails. In this …
[HTML][HTML] The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression
…, J Frampton, P Garcia, MG Tomlinson - Journal of Biological …, 2012 - ASBMB
A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitous transmembrane metalloprotease
that cleaves the extracellular regions from over 40 different transmembrane target …
that cleaves the extracellular regions from over 40 different transmembrane target …
CLEC-2 activates Syk through dimerization
…, J Mori, JA Eble, MG Tomlinson… - Blood, The Journal …, 2010 - ashpublications.org
The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases,
leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, …
leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, …
[HTML][HTML] A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B …
YA Senis, MG Tomlinson, A García, S Dumon… - Molecular & cellular …, 2007 - ASBMB
The platelet surface is poorly characterized due to the low abundance of many membrane
proteins and the lack of specialist tools for their investigation. In this study we identified novel …
proteins and the lack of specialist tools for their investigation. In this study we identified novel …
TGF‐β1 down‐regulates Th2 development and results in decreased IL‐4‐induced STAT6 activation and GATA‐3 expression
…, EE Murphy, C Crain, MG Tomlinson… - European journal of …, 2000 - Wiley Online Library
TGF‐β plays an important role in immune regulation in vivo and affects T cell differentiation
in vitro. Here we describe how TGF‐β modulates Th2 development in vitro and investigate its …
in vitro. Here we describe how TGF‐β modulates Th2 development in vitro and investigate its …
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis
YA Senis, MG Tomlinson, S Ellison… - Blood, The Journal …, 2009 - ashpublications.org
Platelets play a fundamental role in hemostasis and thrombosis. They are also involved in
pathologic conditions resulting from blocked blood vessels, including myocardial infarction …
pathologic conditions resulting from blocked blood vessels, including myocardial infarction …
Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids
AL Matthews, PJ Noy, JS Reyat, MG Tomlinson - Platelets, 2017 - Taylor & Francis
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane “molecular
scissors” which proteolytically cleave, or shed, the extracellular regions of other …
scissors” which proteolytically cleave, or shed, the extracellular regions of other …
[HTML][HTML] TspanC8 tetraspanins and a disintegrin and metalloprotease 10 (ADAM10) interact via their extracellular regions: evidence for distinct binding mechanisms …
…, DA Rogers, GE Rainger, MG Tomlinson - Journal of Biological …, 2016 - ASBMB
A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane
metalloprotease that cleaves the extracellular regions from its transmembrane substrates. …
metalloprotease that cleaves the extracellular regions from its transmembrane substrates. …