Background Molecularly targeted agents have been reported to have anti-tumour activity for
patients whose tumours harbour the matching molecular alteration. These results have led …

Metastasis is the main cause of death for patients with breast cancer. Many studies have
characterized the genomic landscape of breast cancer during its early stages. However, there is …

Background Major advances have been achieved in the characterization of early breast cancer
(eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes…

Cell-free tumor DNA (ctDNA) has the potential to enable non-invasive diagnostic tests for
personalized medicine in providing similar molecular information as that derived from invasive …

Cancer progression is driven in part by genomic alterations 1 . The genomic characterization
of cancers has shown interpatient heterogeneity regarding driver alterations 2 , leading to …

The formation of G protein (heterotrimeric guanine nucleotide–binding protein)–coupled
receptor (GPCR) heteromers enables signaling diversification and holds great promise for …

Motivation: Because of its low cost, amplicon sequencing, also known as ultra-deep targeted
sequencing, is now becoming widely used in oncology for detection of actionable mutations…

Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT), a
close interrelationship between both has long been suspected. The present study reveals a …

Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance
immune-mediated tumor control through increased phagocytosis, cell death, and antigen …

Simple Summary Immunotherapy has made a breakthrough in medical oncology with the
approval of several immune checkpoint inhibitors in multiple cancer types. Since only a …