Introduction: The combination of a targeted biomolecule that specifically defines the target
and a radionuclide that delivers a cytotoxic payload offers a specific way to destroy cancer …

Immuno-imaging is a developing technology that aims at studying disease in patients using
imaging techniques such as positron emission tomography in combination with radiolabeled …

Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …

Nanobodies are the smallest fully functional antigen-binding antibody fragments possessing
ideal properties as probes for molecular imaging. In this study we labeled the anti–human …

RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks
due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. …

A compound's intratumoural distribution is an important determinant for the effectiveness of
molecular therapy or imaging. Antibodies (Abs), though often used in the design of targeted …

Tumor-associated macrophages constitute a major component of the stroma of solid tumors,
encompassing distinct subpopulations with different characteristics and functions. We …

Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial
pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing …

Introduction: The integration of diagnostic testing for the presence of a molecular target is of
interest to predict successful targeted radionuclide therapy (TRNT). This so-called ‘…

… are senior clinical investigators and Matthias D’Huyvetter is postdoctoral researcher of the
… for Precirix NV/SA and, together with Matthias D’Huyvetter and Jens De Vos, hold ownership …