Stimulating the effector functions of tumor-infiltrating T lymphocytes (TIL) in primary and
metastatic tumors could improve active and adoptive T-cell therapies for cancer. Abnormal …

The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence of …

In this study we used TEPITOPE, a new epitope prediction software, to identify sequence
segments on the MAGE-3 protein with promiscuous binding to histocompatibility leukocyte …

The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence
progression of extramucosal tumors is poorly understood. Here we provide evidence …

The tumor is a hostile microenvironment for T lymphocytes. Indeed, irregular blood flow, and
endothelial cell (EC) anergy that characterize most solid tumors hamper leukocyte adhesion…

Abnormal tumor vasculature impairs T lymphocyte adhesion to endothelial cells and lymphocyte
extravasation into neoplastic tissues, limiting the therapeutic potential of both active and …

Apoptosis allows the clearance of unwanted cells from living tissues without causing inflammation.
Processing of phagocytosed apoptotic cells yields Ags that access the cytosol and the …

We have recently reported that lowering the pH to values that are frequently detected in
tumors causes reversible anergy in both human and mouse CD8 + T lymphocytes in vitro. The …

Many preclinical studies of cancer immunotherapy are based on the testing of a single
vaccination strategy in several tumor models. Moreover, most of those studies used xenogeneic …

Precociously disseminated cancer cells may seed quiescent sites of future metastasis if they
can protect themselves from immune surveillance. However, there is little knowledge about …