Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics
in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages …

Camelidae possess an unusual class of antibodies devoid of light chains. Nanobodies are
intact antigen-binding fragments that are stable, easily generated against different targets, …

Purpose Overexpression of the epidermal growth factor receptor (EGFR) occurs with high
incidence in various carcinomas. The oncogenic expression of the receptor has been …

Nanobodies are the smallest fully functional antigen-binding antibody fragments possessing
ideal properties as probes for molecular imaging. In this study we labeled the anti–human …

Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a
promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess …

… Marleen Keyaerts received research funding from Camel-IDS. Karine Breckpot, Nick Devoogdt
and Marleen Keyaerts … Nick Devoogdt and Marleen Keyaerts have ownership in AbScint, …

Introduction: The combination of a targeted biomolecule that specifically defines the target
and a radionuclide that delivers a cytotoxic payload offers a specific way to destroy cancer …

Lentiviral vectors are promising vaccine vector candidates that have been tested extensively
in preclinical models of infectious disease and cancer immunotherapy. They are also used …

Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …

Background Treatment with anti-PD1 monoclonal antibodies improves the survival of metastatic
melanoma patients but only a subgroup of patients benefits from durable disease control…