Selection and characterization of HER2/neu-binding affibody ligands

M Wikman, AC Steffen, E Gunneriusson… - Protein Engineering …, 2004 - academic.oup.com
Affibody® (affibody) ligands that are specific for the extracellular domain of human epidermal
growth factor receptor 2 (HER2/neu) have been selected by phage display technology from …

Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors

A Orlova, FY Nilsson, M Wikman… - Journal of Nuclear …, 2006 - Soc Nuclear Med
In vivo diagnosis with cancer-specific targeting agents that have optimal characteristics for
imaging is an important development in treatment planning for cancer patients. …

In Vitro Characterization of a Bivalent Anti-HER-2 Affibody with Potential for Radionuclide-Based Diagnostics

AC Steffen, M Wikman, V Tolmachev… - Cancer biotherapy & …, 2005 - liebertpub.com
The 185 kDa transmembrane glycoprotein human epidermal growth factor receptor 2 (HER-2)
(p185/neu, c-ErbB-2) is overexpressed in breast and ovarian cancers. Overexpression in …

Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice

AC Steffen, A Orlova, M Wikman, FY Nilsson… - European journal of …, 2006 - Springer
Purpose Targeted delivery of radionuclides for diagnostic and therapeutic applications has
until recently largely been limited to receptor ligands, antibodies and antibody-derived …

Internet-based self-sampling for Chlamydia trachomatis testing: a national evaluation in Sweden

J Söderqvist, K Gullsby, L Stark, M Wikman… - Sexually transmitted …, 2020 - sti.bmj.com
Objective Internet-based testing for Chlamydia trachomatis (CT) with self-sampling at home
has gradually been implemented in Sweden since 2006 as a free-of-charge service within …

Immunogenicity and protective effect against murine cerebral neosporosis of recombinant NcSRS2 in different iscom formulations

S Pinitkiatisakul, M Friedman, M Wikman, JG Mattsson… - Vaccine, 2007 - Elsevier
Recombinant NcSRS2, a major immunodominant surface antigen of the intracellular
protozoan parasite Neospora caninum, was used as a model antigen to compare the …

Enhancement of DNA vaccine potency by linkage of Plasmodium falciparum malarial antigen gene fused with a fragment of HSP70 gene

KR Qazi, M Wikman, NM Vasconcelos, K Berzins… - Vaccine, 2005 - Elsevier
Finding an appropriate adjuvant for human vaccination is crucial. HSPs have been shown
to act as adjuvants when coadministered with peptide antigens or given as fusion proteins. …

Immunisation of mice against neosporosis with recombinant NcSRS2 iscoms

S Pinitkiatisakul, JG Mattsson, M Wikman… - Veterinary …, 2005 - Elsevier
The coccidian parasite Neospora caninum is an intracellular protozoan, causing abortion in
cattle in many countries around the world. In this study, the protective potential of the major N…

Selection and characterization of an HIV‐1 gp120‐binding affibody ligand

M Wikman, E Rowcliffe, M Friedman… - Biotechnology and …, 2006 - Wiley Online Library
To evaluate the possibility of generating novel proteins binding to highly glycosylated viral
proteins, affibody ligands were selected by bacteriophage display technology to the HIV‐1 …

General strategies for efficient adjuvant incorporation of recombinant subunit immunogens

M Wikman, M Friedman, S Pinitkiatisakul, C Andersson… - Vaccine, 2005 - Elsevier
We have previously reported strategies for Escherichia coli production of recombinant
immunogens fused to hydrophobic peptides or lipid tags to improve their capacity to be …