The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies
that rely on endogenous or adoptively transferred T cells, however, the mechanisms are …

The therapeutic efficacy of adoptive transfer of T cells transduced with chimeric antigen
receptors (CARs) has been limited in the treatment of solid cancers, partly due to tumor antigen …

Cooperation of cancer cells with stromal cells, such as cancer-associated fibroblasts (CAFs),
has been revealed as a mechanism sustaining cancer cell survival and growth. In the …

Given the growing interest and promising preliminary results of immunotherapy in malignant
pleural mesothelioma (MPM), it has become important to more fully understand the immune …

Precision-cut tumor slices (PCTS) have recently emerged as important ex vivo human tumor
models, offering the opportunity to study individual patient responses to targeted …

Background: The cellular autophagic response to radiation is complex. Various cells and
tissues respond differentially to radiation, depending on both the dose of exposure and the time …

Fibroblast activation protein (FAP), a cell surface serine protease, is upregulated on a subset
of activated fibroblasts (often distinct from α-smooth muscle actin-expressing myofibroblasts…

Aims Lung cancer is one of the main causes of cancer-related deaths worldwide and
radiotherapy is a major treatment of choice. However, radioresistance is a main reason for …

Objective : Cancer cell radioresistance is a stumbling block in radiation therapy. The activity
in the nuclear factor kappa B (NFκB) pathway correlates with anti-apoptotic mechanisms and …

Purpose: Despite the success of chimeric antigen receptor (CAR) T-cell therapy against
hematologic malignancies, successful targeting of solid tumors with CAR T cells has been …