Large-scale structural topology optimization has always suffered from prohibitively high
computational costs that have till date hindered its widespread use in industrial design. The first …

Despite a solid theoretical foundation and straightforward application to structural design
problems, 3D topology optimization still suffers from a prohibitively high computational effort …

Additive printing allows the “single step” production of virtually any complex mechanical
component. However, the manufacturing process involves a layer-by-layer deposition of material…

This paper proposes a novel approach for multi-objective optimization when the criteria of
interest rely on a functional output from an expensive-to-evaluate numerical simulator. More …

The common issue of surrogate models is to make good use of sampling data. In theory, the
higher the fidelity of sampling data provided, the more accurate the approximation model …

While studies in metamodel-assisted optimization predominantly involve continuous variables,
this paper explores the additional presence of categorical data, representing for instance …

Novel promising strategies for combination with sorafenib are urgently needed to enhance
its clinical benefit and overcome toxicity in hepatocellular carcinoma (HCC). the molecular …

Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized
antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to …

This study concerns optimization of shapes, locations, and dimensions of internal cooling
passages within a turbine vane under severe environments. The basic aim is to achieve a …

Most of the methods used today for handling local stress constraints in topology optimization,
fail to directly address the non-self-adjointness of the stress-constrained topology …