The blood-brain tumor barrier (BTB) limits the delivery of therapeutic drugs to brain tumors.
We demonstrate in a rat brain tumor (RG2) model an enhanced drug delivery to brain tumor …

Brain tumor microvessels/capillaries limit drug delivery to tumors by forming a blood-brain
tumor barrier (BTB). The BTB overexpresses ATP-sensitive potassium (K ATP ) channels that …

Benign melanocytic nevi and cutaneous melanomas can be difficult to differentiate by means
of routine microscopic analysis. Recent evidence has suggested that cytogenomic analysis …

Although diagnosis of high-grade uterine mesenchymal tumors (UMTs) exhibiting classic
morphologic features is straightforward, diagnosis is more challenging in tumors in which …

Spitzoid neoplasms are a distinct group of melanocytic tumors. Genetically, they lack mutations
in common melanoma-associated oncogenes. Recent studies have shown that spitzoid …

Even though the blood-brain tumor barrier (BTB) is more permeable than the blood-brain
barrier (BBB), the BTB still significantly restricts the delivery of anticancer drugs to brain tumors. …

In patients with multiple myeloma, plasmablastic transformation in the bone marrow is rare
and associated with poor outcomes. The significance of discordant extramedullary …

Background In recent years, digoxin use has been on the decline, with decreased incidence
of digoxin toxicity. Hence, digoxin toxicity, when it occurs, remains an elusive diagnosis to …

The oncogene v-akt was isolated from a retrovirus that induced murine thymic lymphomas.
Transgenic mice expressing a constitutively activated form of the cellular homologue Akt2 …

Evolution of poorly differentiated chordoma from conventional chordoma has not been
previously reported. We encountered a case of a poorly differentiated chordoma with evidence of …