Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth,
metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that …

Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell
lines in vitro and tumor development in vivo in immune-deficient xenografts. However, this …

Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in
tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly …

Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy,
the immunosuppressive factors induced by radiation on tumor cells remain to be …

Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …

A small catalytic DNA, known as the 10–23 DNA enzyme or deoxyribozyme, has been shown
to efficiently hydrolyze RNA at purine-pyrimidine (RY) junctions in vitro. Although these …

Current understanding of key transcription factors regulating angiogenesis is limited. Here
we show that RNA-cleaving phosphodiester-linked DNA-based enzymes (DNAzymes), …

Background The latent membrane protein 1 (LMP1) encoded by EBV is expressed in the
majority of EBV-associated human malignancies and has been suggested to be one of the …

Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types,
including head and neck cancers. However, acquired drug resistance results in the failure …

Background LncRNAs have been shown to play essential roles in cancer therapeutic
response. However, the detailed mechanism of lncRNAs in temozolomide (TMZ) resistance in …