[HTML][HTML] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 …
Y Zheng, MW Zhuang, L Han, J Zhang… - Signal transduction and …, 2020 - nature.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected more than 10 …
coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected more than 10 …
Brain‐Targeted Aggregation‐Induced‐Emission Nanoparticles with Near‐Infrared Imaging at 1550 nm Boosts Orthotopic Glioblastoma Theranostics
A remaining challenge in the treatment of glioblastoma multiforme (GBM) is surmounting the
blood–brain barrier (BBB). Such a challenge prevents the development of efficient …
blood–brain barrier (BBB). Such a challenge prevents the development of efficient …
SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling …
L Han, MW Zhuang, J Deng, Y Zheng… - Journal of medical …, 2021 - Wiley Online Library
The suppression of types I and III interferon (IFN) responses by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus disease …
syndrome coronavirus 2 (SARS‐CoV‐2) contributes to the pathogenesis of coronavirus disease …
Stability of polydopamine and poly (DOPA) melanin-like films on the surface of polymer membranes under strongly acidic and alkaline conditions
H Wei, J Ren, B Han, L Xu, L Han, L Jia - Colloids and Surfaces B …, 2013 - Elsevier
This study investigated the stability of polydopamine and poly(3,4-dihydroxyphenylalanine) (poly(DOPA))
melanin-like films on the surface of polymer substrates. Three polymer …
melanin-like films on the surface of polymer substrates. Three polymer …
[HTML][HTML] SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
Y Zheng, J Deng, L Han, MW Zhuang, Y Xu… - Signal transduction and …, 2022 - nature.com
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate
network of antiviral host responses to establish infection and spread. The nucleic acid-induced …
network of antiviral host responses to establish infection and spread. The nucleic acid-induced …
SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy
L Han, Y Zheng, J Deng, ML Nan, Y Xiao… - Journal of medical …, 2022 - Wiley Online Library
A characteristic feature of COVID‐19, the disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) infection, is the dysregulated immune response with …
syndrome coronavirus 2 (SARS‐CoV‐2) infection, is the dysregulated immune response with …
Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
…, Y Wu, S Zhou, L Lyu, M Yang, J Xiong, L Han… - Neurobiology of …, 2018 - Elsevier
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
Gradient biomaterials and their influences on cell migration
Cell migration participates in a variety of physiological and pathological processes such as
embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue …
embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue …
BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer
B Liu, X Liu, L Han, X Chen, X Wu… - Proceedings of the …, 2022 - National Acad Sciences
BRD4 is well known for its role in super-enhancer organization and transcription activation
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …
Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
…, X Pang, P Shangguan, Y Liu, L Han… - Angewandte Chemie …, 2023 - Wiley Online Library
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …