[HTML][HTML] ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
W Muriithi, LW Macharia, CP Heming… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
The ATP-binding cassette transporters (ABC transporters) have been intensely studied over
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, …
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, …
[PDF][PDF] P-glycoprotein and cancer: what do we currently know?
CP Heming, W Muriithi, LW Macharia… - Heliyon, 2022 - cell.com
Acquired resistance during cancer treatment is unfortunately a frequent event. There are
several reasons for this, including the ability of the ATP-binding cassette transporters (ABC …
several reasons for this, including the ability of the ATP-binding cassette transporters (ABC …
GBM-derived Wnt3a induces M2-like phenotype in microglial cells through Wnt/β-catenin signaling
…, J Balça-Silva, ACC Fonseca, LW Macharia… - Molecular …, 2019 - Springer
Glioblastoma is an extremely aggressive and deadly brain tumor known for its striking cellular
heterogeneity and capability to communicate with microenvironment components, such as …
heterogeneity and capability to communicate with microenvironment components, such as …
[HTML][HTML] The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines
LW Macharia, W Muriithi, CP Heming, DK Nyaga… - BMC cancer, 2021 - Springer
Background Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia
has been shown to reprogram cells towards a stem cell phenotype associated with self-…
has been shown to reprogram cells towards a stem cell phenotype associated with self-…
[HTML][HTML] MicroRNAs, hypoxia and the stem-like state as contributors to cancer aggressiveness
LW Macharia, CM Wanjiru, MW Mureithi… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in
cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in …
cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in …
[HTML][HTML] Cancer in Kenya: types and infection-attributable. Data from the adult population of two National referral hospitals (2008-2012)
LW Macharia, MW Mureithi, O Anzala - AAS Open Research, 2018 - ncbi.nlm.nih.gov
Background: Cancer in Africa is an emerging health problem. In Kenya it ranks third as a
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …
[HTML][HTML] Evaluation of MiRNA Expression in Glioblastoma Stem-Like Cells: A Comparison between Normoxia and Hypoxia Microenvironment
LW Macharia, W Muriithi, DK Nyaga… - Onco, 2022 - mdpi.com
Purpose: Glioblastoma is an aggressive and incurable brain tumor whose progression is driven
in part by glioblastoma stem cells, which are also responsible for the tumor’s low therapy …
in part by glioblastoma stem cells, which are also responsible for the tumor’s low therapy …
P-glycoprotein and cancer: what do we currently know?
CP Heming, W Muriithi, LW Macharia… - molecules - europepmc.org
Acquired resistance during cancer treatment is unfortunately a frequent event. There are
several reasons for this, including the ability of the ATP-binding cassette transporters (ABC …
several reasons for this, including the ability of the ATP-binding cassette transporters (ABC …
[PDF][PDF] Cancer in Kenya: types and infection-attributable. Dat a from two National referral hospitals [version 3; peer review
LW Macharia, MW Mureithi, O Anzala - … .s3.eu-west-1.amazonaws.com
Background: Cancer in Africa is an emerging health problem. In Kenya it ranks third as a
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …
[PDF][PDF] Cancer in Kenya: types and infection-attributable. Dat a from the adult population of two National referral hospital s (2008-2012)[version 4; peer review: 1 …
LW Macharia, MW Mureithi, O Anzala - … .s3.eu-west-1.amazonaws.com
Background: Cancer in Africa is an emerging health problem. In Kenya it ranks third as a
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …
cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer …