In 1980, Ludwig and colleagues described a series of patients with liver histology
characterized by the accumulation of fat and the presence of hepatic necroinflammation in the …

Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as reflected …

T-cadherin delineates endothelial, myoepithelial, and ductal epithelial cells in the normal
mouse mammary gland, and becomes progressively restricted to the vasculature during …

Advanced liver fibrosis in nonalcoholic steatohepatitis (NASH) is often accompanied by a
reduction in hepatic fat to the point of complete fat loss (burnt‐out NASH), but the mechanisms …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor
prognosis worldwide. While early stage tumours can be treated with curative approaches …

Aptamers, also known as chemical antibodies, are single-stranded nucleic acid oligonucleotides
which bind to their targets with high specificity and affinity. They are typically selected …

Fructose consumption has dramatically increased in the last 30 years. The principal form has
been in the form of high-fructose corn syrup found in soft drinks and processed food. The …

Obesity is linked to increased cancer risk. Pathological expansion of adipose tissue impacts
adipocyte function and secretion of hormonal factors regulating tissue homeostasis and …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths in the
world, and for patients with advanced disease there are few therapeutic options available. …

The interleukin-6 (IL-6)/STAT3 signaling regulates survival and proliferation of intestinal
epithelial cells and plays an important role in the pathogenesis of inflammatory bowel disease …