Repair of and checkpoint response to topoisomerase I-mediated DNA damage
…, O Sordet, H Takemura, S Antony, LH Meng… - Mutation Research …, 2003 - Elsevier
Topoisomerase I (Top1) catalyzes two transesterification reactions: single-strand DNA
cleavage and religation that are normally coupled for the relaxation of DNA supercoiling in …
cleavage and religation that are normally coupled for the relaxation of DNA supercoiling in …
A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity
H Huang, Q Chen, X Ku, L Meng, L Lin… - Journal of medicinal …, 2010 - ACS Publications
A series of novel thiosemicarbazone derivatives bearing condensed heterocyclic
carboxaldehyde moieties were designed and synthesized. Among them, TSC24 exhibited broad …
carboxaldehyde moieties were designed and synthesized. Among them, TSC24 exhibited broad …
[HTML][HTML] Antioxidant Activities of Polyphenols Extracted from Perilla frutescens Varieties
L Meng, YF Lozano, EM Gaydou, B Li - Molecules, 2008 - mdpi.com
Various cultivars of Perilla frutescens (L.) (var. crispa and var. frutescens) Britt. were harvested
in China and Japan. They were easily differentiated on the basis of their foliage color, that …
in China and Japan. They were easily differentiated on the basis of their foliage color, that …
Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain
Y Qin, L Meng, C Hu, W Duan, Z Zuo, L Lin… - Molecular cancer …, 2007 - AACR
This study is intended to characterize the cellular target of gambogic acid (GA), a natural
product isolated from the gamboge resin of Garcinia hurburyi tree, which possesses potent in …
product isolated from the gamboge resin of Garcinia hurburyi tree, which possesses potent in …
Crystal structures of PI3Kα complexed with PI103 and its derivatives: new directions for inhibitors design
…, Y Luo, QC Shen, J Ding, L Meng… - ACS medicinal …, 2014 - ACS Publications
The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays important roles in cell
proliferation, growth, and survival. Hyperactivated PI3K is frequently found in a wide variety of …
proliferation, growth, and survival. Hyperactivated PI3K is frequently found in a wide variety of …
Prediction of soil organic matter using multi-temporal satellite images in the Songnen Plain, China
X Dou, X Wang, H Liu, X Zhang, L Meng, Y Pan, Z Yu… - Geoderma, 2019 - Elsevier
Due to confounding factors such as crop residue and soil moisture, soil organic matter (SOM)
is usually estimated from soil samples in a laboratory or in the field at a local scale. In this …
is usually estimated from soil samples in a laboratory or in the field at a local scale. In this …
[HTML][HTML] Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA …
…, VA Rao, O Sordet, T Furuta, ZH Miao, LH Meng… - Journal of Biological …, 2006 - ASBMB
The Mre11·Rad50·Nbs1 (MRN) complex binds DNA double strand breaks to repair DNA
and activate checkpoints. We report MRN deficiency in three of seven colon carcinoma cell …
and activate checkpoints. We report MRN deficiency in three of seven colon carcinoma cell …
Discovery of 7H-Pyrrolo [2, 3-d] pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors
Hematopoietic progenitor kinase 1 (HPK1) is predominantly expressed in hematopoietic
cells and is a negative regulator of T cell receptor (TCR) signaling. Recent studies have …
cells and is a negative regulator of T cell receptor (TCR) signaling. Recent studies have …
Phosphorylation of BLM, dissociation from topoisomerase IIIα, and colocalization with γ-H2AX after topoisomerase I-induced replication damage
VA Rao, AM Fan, LH Meng, CF Doe… - … and cellular biology, 2005 - Taylor & Francis
Topoisomerase I-associated DNA single-strand breaks selectively trapped by camptothecins
are lethal after being converted to double-strand breaks by replication fork collisions. BLM (…
are lethal after being converted to double-strand breaks by replication fork collisions. BLM (…
Anthocyanin and Flavonoid Production from Perilla frutescens: Pilot Plant Scale Processing Including Cross-Flow Microfiltration and Reverse Osmosis
L Meng, Y Lozano, I Bombarda… - Journal of agricultural …, 2006 - ACS Publications
Extraction and concentration at a pilot plant scale of anthocyanins and flavonoids from Perilla
frutescens var. frutescens harvested in the Guangzhou area of China were investigated. …
frutescens var. frutescens harvested in the Guangzhou area of China were investigated. …
