… For H-Ras, membrane binding of mutant H-Ras protein that lacks palmate attachment is only
5–10% of the fully modified H-Ras protein, which leads to reduced H-Ras activity [104, 105]…

Background The gut microbiota is closely associated with gastrointestinal (GI) motility disorder,
but the mechanism(s) by which bacteria interact with and affect host GI motility remains …

… In contrast to H 2 S function in the liver, reports of H 2 S functions in adipose tissue are
controversial, while both stimulatory and inhibitory effects of H 2 S on glucose uptake in adipose …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic.
Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-…

Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated
insulin resistance remains unknown. Here, we identify membrane-bound matrix …

GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of growth/differentiation
factor 15 (GDF15/MIC-1), considered a key signaling axis in energy …

Early childhood is a critical period for development, and early life stress may increase the risk
of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal …

Epidemiology studies indicate that consumption of high-fat diet (HFD) is directly associated
with the development of colorectal cancer (CRC). However, the exact component in HFD and …

Dear Editor, Toll-like receptor 4 (TLR4) is a rational therapeutic target. We have discovered
that baicalein directly binds to TLR4, which is a strategy to inhibit TLR4 activity. In our study, …

Ulcerative colitis (UC) causes chronic inflammation and damage to the colonic mucosal
layer. Recent studies have reported significant changes in phosphatidylcholine (PC) and …