Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels
NS Ningaraj, M Rao, K Hashizume, K Asotra… - Journal of Pharmacology …, 2002 - ASPET
The blood-brain tumor barrier (BTB) limits the delivery of therapeutic drugs to brain tumors.
We demonstrate in a rat brain tumor (RG2) model an enhanced drug delivery to brain tumor …
We demonstrate in a rat brain tumor (RG2) model an enhanced drug delivery to brain tumor …
Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4
K Hashizume, KL Black - Journal of Neuropathology & …, 2002 - academic.oup.com
Bradykinin and leukotriene C4 (LTC4) have been shown to increase molecular transport across
the blood-tumor barrier (BTB). The aim of this study was to quantitatively assess whether …
the blood-tumor barrier (BTB). The aim of this study was to quantitatively assess whether …
Recent improvements in cleanliness in high carbon chromium bearing steel
Y Kato, T Masuda, K Kawakami, K Hashizume - ISIJ international, 1996 - jstage.jst.go.jp
Recent changesin the economicsituation have made cost reduction morenecessary, even
while heavier-duty andmorereliable machineparts are neededfor improved fuel economyand …
while heavier-duty andmorereliable machineparts are neededfor improved fuel economyand …
Correlation between bradykinin-induced blood–tumor barrier permeability and B2 receptor expression in experimental brain tumors
Y Liu, K Hashizume, Z Chen, K Samoto… - Neurological …, 2001 - Taylor & Francis
Localization of B2 receptors in brain tumor cells and microvessel endothelial cells of the
brain tumors was investigated to study the differential sensitivity of brain tumors to bradykinin. …
brain tumors was investigated to study the differential sensitivity of brain tumors to bradykinin. …
Giant Aneurysm of the Azygos Anterior Cerebral Artery Associated with Acute Subdural Hematoma—Case Report—
K HASHIZUME, H Nukui, T HORIKOSHI… - Neurologia medico …, 1992 - jstage.jst.go.jp
A ruptured giant aneurysm of the azygos anterior cerebral artery (ACA) associated with an
acute sub dural hematoma (SDH) occurred in a 67-year-old male with two episodes of …
acute sub dural hematoma (SDH) occurred in a 67-year-old male with two episodes of …
A herpes simplex virus type 1 mutant with γ34. 5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice
K Samoto, M Ehtesham, GC Perng, K Hashizume… - …, 2002 - journals.lww.com
OBJECTIVE: We previously constructed a novel recombinant herpes simplex virus with
deletions in the γ34. 5 and LAT genes. LAT was replaced by the gene for green fluorescent …
deletions in the γ34. 5 and LAT genes. LAT was replaced by the gene for green fluorescent …
Xenon contrast CT-CBF measurements in high-intensity foci on T2-weighted MR images in centrum semiovale of asymptomatic individuals
N Miyazawa, T Satoh, K Hashizume, A Fukamachi - Stroke, 1997 - Am Heart Assoc
Background and Purpose White matter lesions (WMLs) on T2-weighted MR images occurring
in the centrum semiovale of normal individuals are a subject of great clinical interest. We …
in the centrum semiovale of normal individuals are a subject of great clinical interest. We …
Long-term follow-up of asymptomatic patients with major artery occlusion: rate of symptomatic change and evaluation of cerebral hemodynamics
N Miyazawa, K Hashizume… - American journal of …, 2001 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The natural history of asymptomatic major cerebral artery
occlusive disease is unclear. Rate of symptomatic change, appearance of new lesions on …
occlusive disease is unclear. Rate of symptomatic change, appearance of new lesions on …
Repeated, short-term ischemia augments bradykinin-mediated opening of the blood–tumor barrier in rats with RG2 glioma
Y Liu, K Hashizume, K Samoto, M Sugita… - Neurological …, 2001 - Taylor & Francis
The objective of this study was to investigate the effects of repeated, short-term ischemia on
bradykininmediated permeability of the blood-brain barrier (BBB) and the blood-tumor …
bradykininmediated permeability of the blood-brain barrier (BBB) and the blood-tumor …
The time course of glucose metabolism in rat cerebral ischemia with middle cerebral artery occlusion-reperfusion model and the effect of MK-801
Y Liu, S Mituska, K Hashizume, T Hosaka… - Neurological …, 1996 - Taylor & Francis
Following cerebral ischemiai, the extracellular concentration of excitatory amino acids
increases, and the excitatory cell death may play an important role contributing to ischemic …
increases, and the excitatory cell death may play an important role contributing to ischemic …