Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including
atherosclerosis. Calcium mineral deposits that frequently accompany atherosclerosis are …

Tumor necrosis factor-alpha (TNF-α) is a potent immunomediator and proinflammatory cytokine
that has been implicated in the pathogenesis of a large number of human diseases. The …

Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially
endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread …

Background— Matrix metalloproteinases (MMPs) are thought to play a prominent role in
atherogenesis and destabilization of plaque. Pericellularly localized membrane-type (MT)-…

Ca 2+ functions as an important signaling messenger right from beginning of life to the final
moments of the end of life. Ca 2+ is needed at several steps of the cell cycle such as early G …

The blood-brain tumor barrier (BTB) limits the delivery of therapeutic drugs to brain tumors.
We demonstrate in a rat brain tumor (RG2) model an enhanced drug delivery to brain tumor …

The cell‐to‐cell channels in gap junctions, formed of proteins called connexins (Cxs),
provide a direct intercellular pathway for the passage of small signaling molecules (≤1 kD) …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable
of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event …

There is extensive epidemiologic and experimental evidence from both animal and human
studies that demonstrates detrimental long-term pulmonary outcomes in the offspring of …

Atherosclerotic arteries frequently become calcified, and these calcium deposits are associated
with a high risk of adverse clinical events. Descriptive studies suggest calcification is an …