Heterogeneity is the major challenge for cancer prevention and therapy. Here, we first
constructed high-resolution spatial transcriptomes of primary liver cancers (PLCs) containing …

This study identifies PD-L1 mRNA as a target of ALKBH5 and reveals a role for ALKBH5 in
regulating the tumor immune microenvironment and immunotherapy efficacy. …

Background & Aims Lack of thorough knowledge about the complicated immune microenvironment
(IM) within a variety of liver metastases (LMs) leads to inappropriate treatment and …

Background and Aims Metabolic reprogramming plays an important role in tumorigenesis.
However, the metabolic types of different tumors are diverse and lack in‐depth study. Here, …

Lenvatinib, a multi-target tyrosine kinase inhibitor (TKI), is an emerging first-line therapy for
hepatocellular carcinoma (HCC). Its application has changed the status of sorafenib as the …

The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many
studies have focused on the role of this signaling pathway in tumor cells. However, it is now …

Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral
disparity always leads to drug resistance. Here, seven hepatobiliary tumor organoids are …

An efficient microwave-assisted simultaneous distillation and extraction (MA-SDE) method
has been developed for the separation of polysaccharides and essential oil from Taxus …

Background & Aims Preoperative obstructive jaundice is usually associated with higher post‐operative
mortality. Although external biliary drainage (EBD) has been widely used to …

The high mutation rate of CTNNB1 (37 %) and Wnt-β-catenin signal-associated genes (54 %)
has been notified in hepatocellular carcinoma (HCC). The activation of Wnt-β-catenin …