Cancers develop within complex tissue environments consisting of diverse innate and adaptive
immune cells, along with stromal cells, vascular networks, and many other cellular and …

Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora
B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating …

Background Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell
therapy has been shown to have activity in patients with relapsed or refractory multiple …

Genomic stability depends on an efficient DNA damage repair system to keep the chromosomes
intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis, but also …

Background Increasing studies have shown that long noncoding RNAs (lncRNAs) are pivotal
regulators participating in carcinogenic progression and tumor metastasis in colorectal …

Chimeric antigen receptor T (CAR‐T) cell therapy has shown promising results for relapsed/refractory
(R/R) acute lymphoblastic leukemia (ALL). The immune response induced by …

p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and
is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 …

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is
overexpressed in diverse carcinomas, including breast cancer. However, the molecular …

Decorin (DCN), an extracellular matrix (ECM) protein, belongs to the small leucine-rich
proteoglycan family. As a pluripotent molecule, DCN regulates the bioactivities of cell growth …