Engineered cysteine residues are particularly convenient for site-specific conjugation of
antibody–drug conjugates (ADC), because no cell engineering and additives are required. …

H+/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play
important roles in the renal tubular secretion of cationic drugs. We have recently identified a …

In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with
nanoparticles are important to develop drug delivery technologies for medical use. We previously …

Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the
development of novel therapeutic approaches. However, reports on such approaches are limited, …

Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed
in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been …

Photodynamic therapy (PDT) utilize a photosensitizing agent and light for cancer therapy. It
exerts anti-cancer effect mainly by inducing vascular occlusion at the irradiated site. By …

An increase in the serum creatine kinase (CK) level is one of the side effects of theophylline;
on rare occasions, the increase may be followed by rhabdomyolysis. Theophylline is often …

Carcinoembryonic antigen (CEA) is a tumor-specific antigen overexpressed in multiple
cancers. CEA is expressed as a membrane protein, a part of which is cleaved from the cell …

… Junko Hanakawa was an attending pediatrician and collected clinical information. Koji
Muroya and Reiko Iwano performed the genetic analysis. Yumi Asakura, Tomonobu Hasegawa, …

Chronic benign neutropenia is seen in children and is usually detected when repeated
occurrence of infectious diseases such as acute otitis media, gastroenteritis, tonsillitis and skin …