A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel
disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-…

In several organ systems, the transitional zone between different types of epithelium is a
hotspot for pre-neoplastic metaplasia and malignancy 1 , 2 , 3 , but the cells of origin for these …

Background Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation
of the gastrointestinal tract. Oxidative stress plays a pivotal role in the pathogenesis of …

The tumor microenvironment (TME) responsive multimodal theranostic nanoplatforms have
attracted great attentions for precision medicine. To design well-defined cascade catalytic …

Background Mesenchymal stem cells (MSCs) therapy is a novel treatment strategy for
cancer and a wide range of diseases with an excessive immune response such as ulcerative …

Cardiac diseases have a high morbidity and mortality and affect the global population. Based
on recent accumulating evidence, Forkhead box O (FOXOs) play important roles in cardiac …

Digestive malignancies are the leading cause of mortality among all neoplasms, contributing
to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung …

Background & Aims The enteric mycobiota is a major component of the human gut microbiota,
but its role in colorectal cancer (CRC) remains largely elusive. We conducted a meta-…

Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study
the role of appendectomy in colorectal cancer (CRC) risk through causing gut microbial …

Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery
more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly …