BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle. Human
Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were found to …

… Junjie Chen Junjie Chen … Chen HT …

DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches
to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here …

The NAD-dependent protein deacetylase Sir2 (silent information regulator 2) regulates
lifespan in several organisms 1 , 2 , 3 . SIRT1, the mammalian orthologue of yeast Sir2, …

BRCA1 localizes to discrete nuclear foci (dots) during S phase. Hydroxyurea-mediated DNA
synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures. …

The carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein is an
evolutionarily conserved module that exists in a large number of proteins from prokaryotes to …

INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …

Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular
responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints 1 . Histone …

MDC1 functions in checkpoint activation and DNA repair following DNA damage. To address
the physiological role of MDC1, we disrupted the MDC1 gene in mice. MDC1 −/− mice …

Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor
53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but …