Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR)
are proposed as the major contributor to the high objective response rate in anti-PD-1 …

Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because
of dMMR-induced neoantigens and activation of the cGAS-STING pathway. While …

NEDD8 is an important regulatory factor in many biological processes. However, the substrates
for neddylation, and the relationship between the ubiquitin and NEDD8 pathways remain …

Background Glioma is the most common and lethal primary brain tumors, and is regarded
as one of the deadliest of human cancers. To date, a growing number of studies have tested …

Long non-coding RNA urothelial carcinoma associated 1 (lncRNA UCA1) promotes cancer
progression and enhances chemoresistance through miR-204-5p in a few cancers. However…

Tumors defective in DNA mismatch repair (dMMR) exhibit microsatellite instability (MSI).
Currently, patients with dMMR tumors are benefitted from anti-PD-1/PDL1-based immune …

Intracerebral hemorrhage (ICH) is a common neurological condition that causes severe
disability and even death. Even though the mechanism is not clear, increasing evidence shows …

Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA
double-strand breaks (DSBs) generated by ionizing radiation (IR). Previously, the DNA …

Background & Aims Although small patient subsets benefit from current targeted strategies
or immunotherapy, gemcitabine remains the first-line drug for pancreatic cancer (PC) …

Stroke is a common cerebrovascular disease in aging populations, and constitutes the second
highest principle cause of mortality and the principle cause of permanent disability, and …