Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics
in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages …

Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly
use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-…

Nanobodies are the smallest fully functional antigen-binding antibody fragments possessing
ideal properties as probes for molecular imaging. In this study we labeled the anti–human …

Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Platelet activation and blood coagulation are complementary, mutually dependent processes
in haemostasis and thrombosis. Platelets interact with several coagulation factors, while …

Platelet adhesion on and activation by components of the extracellular matrix are crucial to
arrest post-traumatic bleeding, but can also harm tissue by occluding diseased vessels. …

Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

Tumor-associated macrophages constitute a major component of the stroma of solid tumors,
encompassing distinct subpopulations with different characteristics and functions. We …

Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals …

CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also
expressed and functional on platelets. We investigated the thrombotic and inflammatory …