Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma
F Chen, Y Fang, R Zhao, J Le, B Zhang… - European Journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
Cell adhesion molecule-mediated therapeutic strategies in atherosclerosis: From a biological basis and molecular mechanism to drug delivery nanosystems
M Yin, C Li, J Le, B Luo, F Yang, Y Fang, M Yang… - Biochemical …, 2021 - Elsevier
Atherosclerosis (AS), characterized by pathological constriction of blood vessels due to chronic
low-grade inflammation and lipid deposition, is a leading cause of human morbidity and …
low-grade inflammation and lipid deposition, is a leading cause of human morbidity and …
[HTML][HTML] A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy
B Zhang, J Jiang, P Wu, J Zou, J Le, J Lin, C Li… - … Pharmaceutica Sinica B, 2021 - Elsevier
Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent
delivery. However, the potential toxicity and unclear internal metabolism of most nano-…
delivery. However, the potential toxicity and unclear internal metabolism of most nano-…
CRISPR/Cas9-based application for cancer therapy: Challenges and solutions for non-viral delivery
YQ Lin, KK Feng, JY Lu, JQ Le, WL Li, BC Zhang… - Journal of Controlled …, 2023 - Elsevier
CRISPR/Cas9 genome editing is a promising therapeutic technique, which makes precise
and rapid gene editing technology possible on account of its high sensitivity and efficiency. …
and rapid gene editing technology possible on account of its high sensitivity and efficiency. …
Carrier-free nanodrugs for in vivo NIR bioimaging and chemo-photothermal synergistic therapy
…, Y Guo, J Zou, P Wu, Y Liao, B Zhang, J Le… - Journal of materials …, 2019 - pubs.rsc.org
The combination of chemotherapy and photothermal therapy displays improved anti-cancer
effects and lower systematic toxicity of a free drug compared with monotherapy. In this study, …
effects and lower systematic toxicity of a free drug compared with monotherapy. In this study, …
Highly sensitive detection and intracellular imaging of microRNAs based on target-triggered cascade catalytic hairpin assembly
L Li, X Fang, J Le, Y Zheng, X Tan, Z Jiang, H Li, J Xu… - Talanta, 2022 - Elsevier
MicroRNAs (miRNAs) have been identified as important biomarkers with great significance
for diagnosis and treatment of various diseases. However, their unique properties, such as …
for diagnosis and treatment of various diseases. However, their unique properties, such as …
Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs
Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization
of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA …
of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA …
Co-delivery of sorafenib and CRISPR/Cas9 based on targeted core–shell hollow mesoporous organosilica nanoparticles for synergistic HCC therapy
…, BY Luo, JJ Zou, PY Wu, JL Jiang, JQ Le… - … Applied Materials & …, 2020 - ACS Publications
The rapid development of CRISPR/Cas9 systems has opened up tantalizing prospects to
sensitize cancers to chemotherapy using efficient targeted genome editing, but safety concerns …
sensitize cancers to chemotherapy using efficient targeted genome editing, but safety concerns …
Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene
J Xu, ZS Wu, Z Wang, H Li, J Le, L Jia - Biomaterials, 2016 - Elsevier
With the biological significance and important advances of nano-scale DNA devices, scientific
activities have been directed toward developing molecular machinery. In this work, we …
activities have been directed toward developing molecular machinery. In this work, we …
Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination
J Xu, ZS Wu, W Shen, J Le, T Zheng, H Li… - Biosensors and …, 2017 - Elsevier
As one of the most exciting building blocks, DNA has gained increasing attention in the
construction of promising nanostructures for various biological and medical purposes. In this …
construction of promising nanostructures for various biological and medical purposes. In this …