Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma

F Chen, Y Fang, R Zhao, J Le, B Zhang… - European Journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …

Cell adhesion molecule-mediated therapeutic strategies in atherosclerosis: From a biological basis and molecular mechanism to drug delivery nanosystems

M Yin, C Li, J Le, B Luo, F Yang, Y Fang, M Yang… - Biochemical …, 2021 - Elsevier
Atherosclerosis (AS), characterized by pathological constriction of blood vessels due to chronic
low-grade inflammation and lipid deposition, is a leading cause of human morbidity and …

[HTML][HTML] A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy

B Zhang, J Jiang, P Wu, J Zou, J Le, J Lin, C Li… - … Pharmaceutica Sinica B, 2021 - Elsevier
Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent
delivery. However, the potential toxicity and unclear internal metabolism of most nano-…

CRISPR/Cas9-based application for cancer therapy: Challenges and solutions for non-viral delivery

YQ Lin, KK Feng, JY Lu, JQ Le, WL Li, BC Zhang… - Journal of Controlled …, 2023 - Elsevier
CRISPR/Cas9 genome editing is a promising therapeutic technique, which makes precise
and rapid gene editing technology possible on account of its high sensitivity and efficiency. …

Carrier-free nanodrugs for in vivo NIR bioimaging and chemo-photothermal synergistic therapy

…, Y Guo, J Zou, P Wu, Y Liao, B Zhang, J Le… - Journal of materials …, 2019 - pubs.rsc.org
The combination of chemotherapy and photothermal therapy displays improved anti-cancer
effects and lower systematic toxicity of a free drug compared with monotherapy. In this study, …

Highly sensitive detection and intracellular imaging of microRNAs based on target-triggered cascade catalytic hairpin assembly

L Li, X Fang, J Le, Y Zheng, X Tan, Z Jiang, H Li, J Xu… - Talanta, 2022 - Elsevier
MicroRNAs (miRNAs) have been identified as important biomarkers with great significance
for diagnosis and treatment of various diseases. However, their unique properties, such as …

Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs

J Xu, ZS Wu, Z Wang, J Le, T Zheng, L Jia - Biomaterials, 2017 - Elsevier
Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization
of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA …

Co-delivery of sorafenib and CRISPR/Cas9 based on targeted core–shell hollow mesoporous organosilica nanoparticles for synergistic HCC therapy

…, BY Luo, JJ Zou, PY Wu, JL Jiang, JQ Le… - … Applied Materials & …, 2020 - ACS Publications
The rapid development of CRISPR/Cas9 systems has opened up tantalizing prospects to
sensitize cancers to chemotherapy using efficient targeted genome editing, but safety concerns …

Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene

J Xu, ZS Wu, Z Wang, H Li, J Le, L Jia - Biomaterials, 2016 - Elsevier
With the biological significance and important advances of nano-scale DNA devices, scientific
activities have been directed toward developing molecular machinery. In this work, we …

Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination

J Xu, ZS Wu, W Shen, J Le, T Zheng, H Li… - Biosensors and …, 2017 - Elsevier
As one of the most exciting building blocks, DNA has gained increasing attention in the
construction of promising nanostructures for various biological and medical purposes. In this …