Osteosarcoma is a relatively uncommon cancer, accounting for 5% of childhood cancers
and 8.9% of cancer-related deaths in children. The overall incidence is five cases per million …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the …

This research aims to improve the current knowledge of groundwater salinisation processes
in coastal aquifers using combined hydrochemical and isotopic parameters and inverse …

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular mechanisms
of etiology and pathogenesis, therefore it remains a challenge for current therapeutic …

BACKGROUND: Osteosarcoma is the most common primary tumor of bone. It is a highly
vascular and extremely destructive malignancy that mainly affects children and young adults. …

Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has
a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells …

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth
muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a …

Over the past decade, heavy metal (HMs) contamination in soil environments has become
severe worldwide. However, their resulting ecological and health risks remained elusive …

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in the
gastrointestinal tract and is associated with mutations of the KIT or PDGFRA gene. In addition, …

Background The administration of second- or third-generation anti-CD19 chimeric antigen
receptor (CAR) T cells has remarkably improved the survival of patients with relapsed or …