Recently, the pharmaceutical industry has heavily emphasized phenotypic drug discovery (PDD),
which relies primarily on knowledge about phenotype changes associated with …

We adopted a rational approach to design cationic lipids for use in formulations to deliver
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-…

RNA interference (RNAi) is a ubiquitous and highly effective biological mechanism to
control gene expression. Over the last few years it has been established that synthetic …

The tensegrity hypothesis holds that the cytoskeleton is a structure whose shape is stabilized
predominantly by the tensile stresses borne by filamentous structures. Accordingly, cell …

Background Thousands of medical staff had been infected with SARS-CoV-2 virus with hundreds
of deaths reported. Such loss could be prevented if there is a serologic assay for SARS-…

In silico prediction of drug-target interactions from heterogeneous biological data can advance
our system-level search for drug molecules and therapeutic targets, which efforts have not …

We describe a novel synchronous detection approach to map the transmission of
mechanical stresses within the cytoplasm of an adherent cell. Using fluorescent protein-labeled …

A novel thin film nanocomposite (TFN) membrane was prepared by incorporating covalent
organic frameworks (COFs) into polyamide (PA) layer on a polyether sulfone (PES) substrate, …

The tensegrity model hypothesizes that cytoskeleton-based microtubules (MTs) carry
compression as they balance a portion of cell contractile stress. To test this hypothesis, we used …

In recent years, much attention has been focused on developing heterogeneous catalyst for
Fenton or photo-Fenton process to reuse the catalyst and avoid the possible pollution …