Toxic Exposure Surveillance System (TESS) data are compiled by the American Association
of Poison Control Centers (AAPCC) in cooperation with the majority of US poison centers. …

Colonization of the gastrointestinal tract (GIT) of human infants with a suitable microbial
community is essential for numerous aspects of health, but the progression of events by which …

Background Microbial life dominates the earth, but many species are difficult or even impossible
to study under laboratory conditions. Sequencing DNA directly from the environment, a …

Introduction Older patients with early breast cancer (EBC) derive modest survival benefit
from chemotherapy but have increased toxicity risk. Data on the impact of chemotherapy for …

Background Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients
but is infrequently offered to older individuals. This study determined if there are fit older …

Introduction Primary endocrine therapy (PET) is used variably in the UK as an alternative to
surgery for older women with operable breast cancer. Guidelines state that only patients with …

Objectives Despite NICE (2009; 2018) guidelines to treat breast cancer patients ‘irrespective
of age’, older women experience differential treatment and worse outcomes beyond that …

Background Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in
older women. This benefit may be small and should be balanced against treatment effect …

Objective Primary endocrine therapy (PET) is an alternative to surgery for oestrogen receptor
positive operable breast cancer in some older women. However the decision to offer PET …

Aim There is emerging evidence supporting early bowel resection (EBR) for ileocaecal Crohn's
disease (CD) as an alternative to conventional escalation of medical therapy (MT). Here, …