DNA damage response–a double-edged sword in cancer prevention and cancer therapy

H Tian, Z Gao, HZ Li, BF Zhang, G Wang, Q Zhang… - Cancer letters, 2015 - Elsevier
Genomic stability depends on an efficient DNA damage repair system to keep the chromosomes
intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis, but also …

Potent anti‐leukemia activities of humanized CD19‐targeted Chimeric antigen receptor T (CAR‐T) cells in patients with relapsed/refractory acute lymphoblastic …

…, K Qi, W Sang, LI Zhenyu, M Shi, H Li… - American journal of …, 2018 - Wiley Online Library
Chimeric antigen receptor T (CAR‐T) cell therapy has shown promising results for relapsed/refractory
(R/R) acute lymphoblastic leukemia (ALL). The immune response induced by …

Long-term follow-up of combination of B-cell maturation antigen and CD19 chimeric antigen receptor T cells in multiple myeloma

…, F Zhu, H Sun, W Sang, D Li, Z Li… - Journal of Clinical …, 2022 - ingentaconnect.com
PURPOSE A combination of anti–B-cell maturation antigen (BCMA) and anti-CD19 chimeric
antigen receptor (CAR) T cells induced high response rates in patients with relapsed or …

Empirical evaluation of smart contract testing: What is the best choice?

M Ren, Z Yin, F Ma, Z Xu, Y Jiang, C Sun, H Li… - Proceedings of the 30th …, 2021 - dl.acm.org
Security of smart contracts has attracted increasing attention in recent years. Many
researchers have devoted themselves to devising testing tools for vulnerability detection. Each …

[HTML][HTML] Targeting brain lesions of non-small cell lung cancer by enhancing CCL2-mediated CAR-T cell migration

H Li, EB Harrison, H Li, K Hirabayashi, J Chen… - Nature …, 2022 - nature.com
Metastatic non-small cell lung cancer (NSCLC) remains largely incurable and the prognosis
is extremely poor once it spreads to the brain. In particular, in patients with brain metastases…

[HTML][HTML] Combination therapy with EpCAM-CAR-NK-92 cells and regorafenib against human colorectal cancer models

…, J Ding, H Liu, H Li, H Li, M Lu, Y Miao, L Li… - Journal of immunology …, 2018 - hindawi.com
Adoptive chimeric antigen receptor-modified T or NK cells (CAR-T or CAR-NK) offer new
options for cancer treatment. CAR-T therapy has achieved encouraging breakthroughs in the …

Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

H Tian, BF Zhang, JH Di, G Jiang, FF Chen, HZ Li, LT Li… - Cancer letters, 2012 - Elsevier
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production
of Reactive Oxygen Species (ROS) and cell’s own antioxidant defenses. As a oxidative …

Anionic nanoplastic contaminants promote Parkinson's disease–associated α-synuclein aggregation

…, AM Duda, E Xu, C Stanhope, A Fu, S Strader, H Li… - Science …, 2023 - science.org
Recent studies have identified increasing levels of nanoplastic pollution in the environment.
Here, we find that anionic nanoplastic contaminants potently precipitate the formation and …

Evmfuzzer: detect evm vulnerabilities via fuzz testing

…, M Ren, F Ma, H Shi, X Yang, Y Jiang, H Li… - Proceedings of the …, 2019 - dl.acm.org
Ethereum Virtual Machine (EVM) is the run-time environment for smart contracts and its
vulnerabilities may lead to serious problems to the Ethereum ecology. With lots of techniques …

Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155

B Zhang, W Zhao, H Li, Y Chen, H Tian, L Li… - Cancer Immunology …, 2016 - Springer
T cell Ig and ITIM domain (TIGIT) is a newly identified inhibitory receptor expressed on T
and natural killer (NK) cells. Cytokine-induced killer (CIK) cells express CD3 and CD56 …