The mammalian liver possesses a remarkable regenerative ability. Two modes of damage
response have been described: (1) The "oval cell" response emanates from the biliary tree …

In vitro 3D organoid systems have revolutionized the modeling of organ development and
diseases in a dish. Fluorescence microscopy has contributed to the characterization of the …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development,
disease, and regeneration. As organoid research expands, the need for clear definitions …

With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature
is becoming the bottleneck in progressing our ability to model human hepatic tissues in …

We reported that Cullin4B-Ring E3 ligase complex (CRL4B) is physically associated with
Polycomb-repressive complex 2 (PRC2). We showed that CRL4B possesses an intrinsic …

The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in
cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila homolog is …

Hereditary spastic paraplegias (HSPs), characterized by progressive and bilateral spasticity
of the legs, are usually caused by developmental failure or degeneration of motor axons in …

The liver is composed of two epithelial cell types: hepatocytes and liver ductal cells. Culture
conditions for expansion of human liver ductal cells in vitro as organoids were previously …

Proliferation and migration of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs)
are critical processes involved in atherosclerosis. Recent studies have revealed that …

Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused
by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of …