[HTML][HTML] Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells
W Zhang, J Su, H Xu, S Yu, Y Liu, Y Zhang, L Sun… - PloS one, 2017 - journals.plos.org
Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a
promising anticancer therapeutic target. Our previous work suggests that coumarin …
promising anticancer therapeutic target. Our previous work suggests that coumarin …
Bridge evolution during the coalescence of immiscible droplets
H Xu, T Wang, Z Che - Journal of Colloid and Interface Science, 2022 - Elsevier
Hypothesis Droplet coalescence is a common phenomenon and plays an important role in
many applications. When two liquid droplets are brought into contact, a liquid bridge forms …
many applications. When two liquid droplets are brought into contact, a liquid bridge forms …
[HTML][HTML] The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization
H Xu, D Li, J Ma, Y Zhao, L Xu, R Tian… - Cancer Biology & …, 2021 - ncbi.nlm.nih.gov
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages
secrete pro-inflammatory factors that inhibit tumor growth and development, whereas …
secrete pro-inflammatory factors that inhibit tumor growth and development, whereas …
[HTML][HTML] Deficiency in IL-33/ST2 axis reshapes mitochondrial metabolism in lipopolysaccharide-stimulated macrophages
H Xu, L Sun, Y He, X Yuan, J Niu, J Su, D Li - Frontiers in immunology, 2019 - frontiersin.org
The polarization and function of macrophages play essential roles in controlling immune
responses. Interleukin (IL)-33 is a member of the IL-1 family that has been shown to influence …
responses. Interleukin (IL)-33 is a member of the IL-1 family that has been shown to influence …
[HTML][HTML] PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis
…, B Sun, J Sheng, S Yu, Y Li, H Xu… - International …, 2018 - spandidos-publications.com
The induction of lesions in nuclear and mitochondrial DNA by cisplatin is only a small
component of its cytostatic/cytotoxic activity. The signaling pathway network in the nucleus and …
component of its cytostatic/cytotoxic activity. The signaling pathway network in the nucleus and …
[HTML][HTML] Inhibition of pyruvate dehydrogenase kinase‑1 by dicoumarol enhances the sensitivity of hepatocellular carcinoma cells to oxaliplatin via metabolic …
H Xu, Y He, J Ma, Y Zhao, Y Liu… - … Journal of Oncology, 2020 - spandidos-publications.com
The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely
related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is …
related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is …
Coalescence of immiscible droplets in liquid environments
H Xu, T Wang, Z Che - Journal of Colloid and Interface Science, 2024 - Elsevier
Hypothesis Droplet coalescence process is important in many applications and has been
studied extensively when two droplets are surrounded by gas. However, the coalescence …
studied extensively when two droplets are surrounded by gas. However, the coalescence …
Regulation of integrated stress response sensitizes U87MG glioblastoma cells to temozolomide through the mitochondrial apoptosis pathway
Y He, H Meng, H Xu, L Fan, Z Zhou, B Xu… - The Anatomical …, 2018 - Wiley Online Library
Glioblastomas are the most frequently diagnosed and worst primary malignancy of the central
nervous system, with very poor prognosis. The first‐line antiglioma drug temozolomide …
nervous system, with very poor prognosis. The first‐line antiglioma drug temozolomide …
Coalescence of immiscible sessile droplets on a partial wetting surface
H Xu, X Ge, T Wang, Z Che - Journal of Fluid Mechanics, 2023 - cambridge.org
Droplet coalescence is a common phenomenon and plays an important role in multidisciplinary
applications. Previous studies mainly consider the coalescence of miscible liquids, even …
applications. Previous studies mainly consider the coalescence of miscible liquids, even …
Hierarchical sheet-like Cu/Zn/Al nanocatalysts derived from LDH/MOF composites for CO2 hydrogenation to methanol
The CO 2 hydrogenation to generate methanol is one of the most promising techniques to
turn waste CO 2 into useful fuel and chemicals in a sustainable manner. Herein, we have …
turn waste CO 2 into useful fuel and chemicals in a sustainable manner. Herein, we have …