User profiles for Hongyan Wang

Hongyan Wang

Duke-NUS Medical School
Verified email at duke-nus.edu.sg
Cited by 3591

[PDF][PDF] Genomic dissection of population substructure of Han Chinese and its implication in association studies

…, H Wang, Y Shen, X Pan, Y He, Y Yang, Y Wang… - The American Journal of …, 2009 - cell.com
To date, most genome-wide association studies (GWAS) and studies of fine-scale population
structure have been conducted primarily on Europeans. Han Chinese, the largest ethnic …

Shale gas reservoir characterisation: A typical case in the southern Sichuan Basin of China

S Chen, Y Zhu, H Wang, H Liu, W Wei, J Fang - Energy, 2011 - Elsevier
The Lower Silurian Longmaxi Formation is an organic-rich (black) mudrock that is widely
considered to be a potential shale gas reservoir in the southern Sichuan Basin (the Yangtze …

Shale gas in China: Characteristics, challenges and prospects (II)

…, Y Wang, X Li, J Huang, S Wang… - Petroleum …, 2016 - ui.adsabs.harvard.edu
This paper mainly discusses the industrialization progress," sweet spot" evaluation criterion,
E&P technologies, success experiences, challenges and prospects of China's shale gas. …

[HTML][HTML] Recent advances in utilizing transcription factors to improve plant abiotic stress tolerance by transgenic technology

H Wang, H Wang, H Shao, X Tang - Frontiers in plant science, 2016 - frontiersin.org
Agricultural production and quality are adversely affected by various abiotic stresses worldwide
and this will be exacerbated by the deterioration of global climate. To feed a growing …

[HTML][HTML] Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning

D Wang, C Zhang, B Wang, B Li, Q Wang, D Liu… - Nature …, 2019 - nature.com
Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing,
but their wide applications are hampered by a lack of knowledge governing guide RNA (…

A genome-wide search for signals of high-altitude adaptation in Tibetans

…, X Pan, J Wang, Y Shen, B Wu, H Wang… - Molecular biology …, 2011 - academic.oup.com
Genetic studies of Tibetans, an ethnic group with a long-lasting presence on the Tibetan
Plateau which is known as the highest plateau in the world, may offer a unique opportunity to …

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

…, H Wang, L Fan, X Wu, A Xin, H Ren, XJ Wang - Free Radical Biology …, 2011 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor regulating
the expression of a battery of cytoprotective genes. Constitutive Nrf2 activation in many …

Biochemical evidence for Ku‐independent backup pathways of NHEJ

H Wang, AR Perrault, Y Takeda, W Qin… - Nucleic acids …, 2003 - academic.oup.com
Cells of higher eukaryotes process within minutes double strand breaks (DSBs) in their
genome using a non‐homologous end joining (NHEJ) apparatus that engages DNA‐PKcs, Ku, …

Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

H Wang, GW Somers, A Bashirullah… - Genes & …, 2006 - genesdev.cshlp.org
The choice of self-renewal versus differentiation is a fundamental issue in stem cell and
cancer biology. Neural progenitors of the Drosophila post-embryonic brain, larval neuroblasts (…

Social potential fields: A distributed behavioral control for autonomous robots

JH Reif, H Wang - Robotics and Autonomous Systems, 1999 - Elsevier
A Very Large Scale Robotic (VLSR) system may consist of from hundreds to perhaps tens of
thousands or more autonomous robots. The costs of robots are going down, and the robots …