MEK inhibitors for the treatment of non-small cell lung cancer

J Han, Y Liu, S Yang, X Wu, H Li, Q Wang - Journal of Hematology & …, 2021 - Springer
BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAPK signaling pathway.
Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell …

EGFR exon 20 insertion mutations in advanced non-small-cell lung cancer: current status and perspectives

J Hou, H Li, S Ma, Z He, S Yang, L Hao, H Zhou… - Biomarker …, 2022 - Springer
Platinum-based chemotherapy was previously the first-choice treatment for lung cancer. The
discovery of epidermal growth factor receptor (EGFR) gene mutations and the development …

[HTML][HTML] LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis

J Chu, H Li, Y Xing, J Jia, J Sheng, L Yang… - Biomedicine & …, 2019 - Elsevier
Background Long non-coding RNAs (lncRNAs) are powerful factors influencing the tumorigenesis
and metastasis of multiple carcinomas. LncRNA MNX1-AS1 plays critical roles in the …

When N7-methyladenosine modification meets cancer: Emerging frontiers and promising therapeutic opportunities

D Du, J He, C Ju, C Wang, H Li, F He, M Zhou - Cancer Letters, 2023 - Elsevier
N 7 -methylguanosine (m 7 G) methylation, one of the most common RNA modifications in
eukaryotes, has recently gained considerable attention. The biological functions of m 7 G …

[HTML][HTML] LncRNA FAM83A-AS1 promotes ESCC progression by regulating miR-214/CDC25B axis

J Jia, H Li, J Chu, J Sheng, C Wang, Z Jia… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Recent researches have pinpointed that long non-coding RNA (lncRNA) was
tightly related to the carcinogenesis. However, the function of lncRNA in esophageal cell …

IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis

…, J Sheng, D Du, J Wan, H Yin, Y Xing, H Li… - Journal of Experimental …, 2022 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is one of the most common
digestive malignancies with relatively high morbidity and mortality. Emerging evidence suggests …

Luminescent gold nanoclusters for in vivo tumor imaging

H Li, H Li, A Wan - Analyst, 2020 - pubs.rsc.org
Fluorescent gold nanoclusters (AuNCs) are emerging as novel imaging contrast agents. These
molecules offer excellent prospects for non-invasive tumor diagnosis strategies because …

EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression

C Ju, M Zhou, D Du, C Wang, J Yao, H Li, Y Luo… - Cell Death & …, 2023 - nature.com
Breast cancer (BC) is one of the most frequent cancer-related deaths in women worldwide.
Studies have shown the potential impact of circRNAs in multiple human tumorigeneses. …

N6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming

M Zhou, J He, Y Li, L Jiang, J Ran, C Wang, C Ju… - Cell Death & …, 2023 - nature.com
Aerobic glycolysis has been considered as a hallmark of colorectal cancer (CRC). However,
the potential functional regulators of glycolysis in CRC remains to be elucidated. In the …

Current advances and future perspectives on the functional roles and clinical implications of circular RNAs in esophageal squamous cell carcinoma: more influential …

C Ju, J He, C Wang, J Sheng, J Jia, D Du, H Li… - Biomarker …, 2022 - Springer
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive gastrointestinal
cancers with high incidence and mortality. Therefore, it is necessary to identify novel …