Simultaneous PET-MRI: a new approach for functional and morphological imaging

…, S Widmaier, M Röcken, RE Nutt, HJ Machulla… - Nature medicine, 2008 - nature.com
Noninvasive imaging at the molecular level is an emerging field in biomedical research.
This paper introduces a new technology synergizing two leading imaging methodologies: …

Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside

M Piert, HJ Machulla, M Picchio, G Reischl… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The study was performed to compare the 18 F-labeled nitroimidazole compound fluoroazomycin
arabinoside ( 18 F-FAZA) with the standard hypoxia tracer fluoromisonidazole ( 18 F-…

The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study

…, KJ Schweitzer, T Gasser, HJ Machulla… - The Lancet …, 2008 - thelancet.com
Background Increased echogenicity of the substantia nigra (SN), as determined by transcranial
sonography (TCS), is characteristic of idiopathic Parkinson's disease (iPD). The results of …

Correlation of stable elevations in striatal μ-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study …

…, DH Braus, G Schumann, HJ Machulla… - Archives of general …, 2005 - jamanetwork.com
Background The pleasant effects of food and alcohol intake are partially mediated by μ-opiate
receptors in the ventral striatum, a central area of the brain reward system. Blockade of μ-…

Assessment of porcine bone metabolism by dynamic [18F] fluoride ion PET: correlation with bone histomorphometry

…, A Stahlschmidt, G Maier, HJ Machulla… - Journal of Nuclear …, 2001 - Soc Nuclear Med
The aim of this study was to quantify regional bone blood flow and [ 18 F]fluoride ion influx
with [ 18 F]fluoride ion PET and correlate the results with specific static and dynamic indices of …

Hypoxia-imaging with 18F-misonidazole and PET: changes of kinetics during radiotherapy of head-and-neck cancer

…, F Paulsen, C Bedeshem, HJ Machulla… - Radiotherapy and …, 2007 - Elsevier
BACKGROUND AND PURPOSE: PET with 18 F-Misonidazole (FMISO-PET) is a non-invasive
method for measuring tumor hypoxia. We analysed changes of FMISO-uptake during …

PET imaging of prostate cancer xenografts with a highly specific antibody against the prostate-specific membrane antigen

…, J Shively, MS Judenhofer, HJ Machulla… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA), a transmembrane glycoprotein, is highly
expressed by virtually all prostate cancers and is currently the focus of several diagnostic and …

[11C] PIB binding in Parkinson's disease dementia

…, M Uebele, G Reischl, T Gasser, HJ Machulla… - Neuroimage, 2008 - Elsevier
[ 11 C]PIB ( 11 C-6-OH benzothiazole) reflects the regional distribution of amyloid (beta-sheeted
proteins) in patients with Alzheimer's disease (AD). Proteinaceous inclusions in …

Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine

…, M Picchio, M Souvatzoglou, HJ Machulla… - Journal of Nuclear …, 2007 - Soc Nuclear Med
We evaluated the predictive value of PET using the hypoxia tracer 18 F-fluoroazomycin
arabinoside ( 18 F-FAZA) for success of radiotherapy in combination with tirapazamine, a …

Central serotonin transporter levels are associated with stress hormone response and anxiety

…, DR Weinberger, D Goldman, HJ Machulla… - …, 2011 - Springer
Rationale Negative mood states are characterized by both stress hormone dysregulation and
serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. …