Oxidative stress plays a critical role in liver tissue damage and in hepatocellular carcinoma (HCC)
initiation and progression. However, the mechanisms that regulate autophagy and …

The aim of this study was to clarify the role of fibroblast-derived Lysyl oxidase-like 2 (LOXL2)
in the development of gastric cancer. The correlation between the clinicopathological …

The prognosis for patients with cancers known for a highly activated stromal reaction,
including diffuse‐type (scirrhous) gastric cancer, consensus molecular subtype 4 (CMS4) …

Aim: This study evaluated the clinicopathological significance of autophagy, an intracellular
degradation system, in gastric cancer. Materials and Methods: The expression levels of three …

Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal
cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and …

Cancer-associated fibroblasts (CAFs) promote tumor malignancy, but the precise transcriptional
mechanisms regulating the acquisition of the CAF phenotype are not well understood. …

Purpose It has been reported that lysyl oxidase (LOX) is a hypoxia-responsive factor and is
associated with the malignant progression of carcinoma. The aim of this study was to clarify …

Mesenchymal colorectal cancer (mCRC) is microsatellite stable (MSS), highly desmoplastic,
with CD8 + T cells excluded to the stromal periphery, resistant to immunotherapy, and …

Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor
suppressor in CRC with reduced expression in metastasis. Given the importance of …

Background/Aims: Lysyl oxidase (LOX) family members play a key role in modifying the primary
tumor microenvironment by crosslinking collagens and elastin in the extracellular matrix. …