Despite a long-suspected role in the development of human colorectal cancer (CRC), the
composition of gut microbiota in CRC patients has not been adequately described. In this study…

Colorectal carcinogenesis involves the overexpression of many immediate-early response
genes associated with growth and inflammation, which significantly alters downstream …

Background Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and
the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many …

After our serum metabonomic study of colorectal cancer (CRC) patients recently published
in J. Proteome Res., we profiled urine metabolites from the same group of CRC patients (…

Recent studies suggest that biofluid-based metabonomics may identify metabolite markers
promising for colorectal cancer (CRC) diagnosis. We report here a follow-up replication study…

Background Emerging evidence suggests a potential relationship between gut microbiota
and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu). …

Purpose: Metabolic phenotyping has provided important biomarker findings, which, unfortunately,
are rarely replicated across different sample sets due to the variations from different …

Limited previous studies focused on the death and progression risk stratification of colorectal
cancer (CRC) lung metastasis patients. The aim of this study is to construct a nomogram …

Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal
tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche …

Distant metastasis (DM) is the main cause of treatment failure in locally advanced rectal cancer.
Adjuvant chemotherapy is usually used for distant control. However, not all patients can …