Formation and segregation of cell lineages forming the heart have been studied extensively
but the underlying gene regulatory networks and epigenetic changes driving cell fate …

Neoadjuvant immune-checkpoint blockade therapy only benefits a limited fraction of patients
with glioblastoma multiforme (GBM). Thus, targeting other immunomodulators on myeloid …

Histone lysine methylation has received a great deal of attention from the chromatin field
over the past 10 years. To date, histone lysine methylations have been demonstrated to play …

DNA methylation is tightly regulated throughout mammalian development, and altered DNA
methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase …

Purpose: Bladder cancer treatment remains a major clinical challenge due to therapy resistance
and a high recurrence rate. Profiling intratumor heterogeneity can reveal the molecular …

Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment
that shapes tumor progress and determines the outcome of therapeutic response. Here, …

Background Regulating T-cell metabolism is crucial for their anticancer activity. Therefore,
understanding the function and metabolism of human tumor-infiltrating T cells is of broad …

Morbidity and mortality of coronavirus disease 2019 (COVID-19) is age-dependent. It
remains unclear whether vertical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1)
in human melanoma, most patients do not experience durable clinical benefit. T-cell …

Macrophages are innate immune cells that are ubiquitously distributed throughout the vertebrate
body. Macrophages orchestrate sophisticated processes in development, homeostasis, …