Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links between …

Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part
because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA …

Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer 1 . Normally,
ROS levels are tightly controlled by an inducible antioxidant program that responds to …

Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling,
differentiation, and survival. In this review, we discuss the types of ROS, their impact on …

The androgen receptor (AR) is a key regulator of prostate growth and the principal drug
target for the treatment of prostate cancer. Previous studies have mapped AR targets and …

We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs
to regulate mRNA transcripts containing common microRNA recognition elements (MREs). …

Tumors have high energetic and anabolic needs for rapid cell growth and proliferation 1 ,
and the serine biosynthetic pathway was recently identified as an important source of …

The mammalian target of rapamycin complex 1 (mTORC1) regulates activation of immune
cells and cellular energy metabolism. While glycolysis has been linked to immune functions, …

Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously
reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate …

Altered metabolism has been implicated in the pathogenesis of inflammatory diseases.
NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological …